Journal of Cancer Research and Therapeutics Close
 

Figure 7: Histopathological analysis: (a) Control group (H and E, ×100) showing normal hepatoparenchyma, portal triad, and normal central vein, (b) the same section of control group showing normal bile duct proliferation with normal portal triad (H and E, ×400), (c) treated group with thioacetamide (200 mg/kg) at the end of 3rd month showing cirrhotic pattern of liver tissue (H and E, ×100), (d) the same section showing septa formed of mainly inflammatory cells adjoining a hepatocytic nodule (H and E, ×400), (e) liver from the 6th month showing cirrhotic pattern with inflammation and nodule formation also observed (H and E, ×100), (f) high-power photomicrograph (H and E, ×400) from the same section showing a portion of a hepatocytic nodule. The hepatocytes in the nodule show atypical features specific to hepatocellular carcinoma such as anisonucleosis, prominent nucleoli, and presence of very large nuclear profiles (arrows). PT = Portal triad, CV = Central vein, H = Hepatocytic Nodules, S = Septae, PV = Portal vein, BD = Bile duct, F = Fibrous Septae

Figure 7: Histopathological analysis: (a) Control group (H and E, ×100) showing normal hepatoparenchyma, portal triad, and normal central vein, (b) the same section of control group showing normal bile duct proliferation with normal portal triad (H and E, ×400), (c) treated group with thioacetamide (200 mg/kg) at the end of 3<sup>rd</sup> month showing cirrhotic pattern of liver tissue (H and E, ×100), (d) the same section showing septa formed of mainly inflammatory cells adjoining a hepatocytic nodule (H and E, ×400), (e) liver from the 6<sup>th</sup> month showing cirrhotic pattern with inflammation and nodule formation also observed (H and E, ×100), (f) high-power photomicrograph (H and E, ×400) from the same section showing a portion of a hepatocytic nodule. The hepatocytes in the nodule show atypical features specific to hepatocellular carcinoma such as anisonucleosis, prominent nucleoli, and presence of very large nuclear profiles (arrows). PT = Portal triad, CV = Central vein, H = Hepatocytic Nodules, S = Septae, PV = Portal vein, BD = Bile duct, F = Fibrous Septae