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Figure 2: Metformin induces cell cycle arrest and apoptosis and inhibits tumor invasion of hepatocellular carcinoma cells. (a) Cell cycle analysis was performed by staining with propidium iodide. (b) SMMC-7721 cells showed typical characteristics of apoptosis. (c) Cell apoptosis was performed by staining with Annexin V and propidium iodide. (d) Metformin induces cell apoptosis in SMMC-7721 cells with irradiation. (e) The invasive cells are stained with crystal violet. (f) Metformin inhibits tumor invasion of SMMC-7721 cells with irradiation. *P < 0.05 versus control group, #P < 0.05 versus irradiation alone group

Figure 2: Metformin induces cell cycle arrest and apoptosis and inhibits tumor invasion of hepatocellular carcinoma cells. (a) Cell cycle analysis was performed by staining with propidium iodide. (b) SMMC-7721 cells showed typical characteristics of apoptosis. (c) Cell apoptosis was performed by staining with Annexin V and propidium iodide. (d) Metformin induces cell apoptosis in SMMC-7721 cells with irradiation. (e) The invasive cells are stained with crystal violet. (f) Metformin inhibits tumor invasion of SMMC-7721 cells with irradiation. *<i>P</i> < 0.05 versus control group, <sup>#</sup><i>P</i> < 0.05 versus irradiation alone group