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Figure 1: Metformin induces increased radiosensitivity in hepatocellular carcinoma cells. SMMC-7721 cells were plated immediately after γ-ray irradiation (0, 2, 4, 6, and 8 Gy) with metformin of 1 mM (a), 5 mM (b), 10 Mm (c), and 20 Mm (d) for 24 h. The surviving fraction was determined by MTT assay and was normalized to control SMMC-7721 cells which were treated with neither irradiation nor metformin. Each experiment was performed in triplicate and data are shown as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001 versus irradiation alone group. IR=Irradiation, Met=Metformin

Figure 1: Metformin induces increased radiosensitivity in hepatocellular carcinoma cells. SMMC-7721 cells were plated immediately after γ-ray irradiation (0, 2, 4, 6, and 8 Gy) with metformin of 1 mM (a), 5 mM (b), 10 Mm (c), and 20 Mm (d) for 24 h. The surviving fraction was determined by MTT assay and was normalized to control SMMC-7721 cells which were treated with neither irradiation nor metformin. Each experiment was performed in triplicate and data are shown as mean ± standard deviation. *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001 versus irradiation alone group. IR=Irradiation, Met=Metformin