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Figure 3: Effect of Solanum nigrum polysaccharide on pathological changes in H and E staining. Forty mice bearing with H22 cells were randomly divided into four groups: model group, cyclophosphamide group (30 mg/kg), and Solanum nigrum polysaccharide groups with low and medium doses of Solanum nigrum polysaccharide (30, 60 mg/kg). A plenty of tumor cells and prominent nucleoli (a, ×400) and the infiltration into adipose tissue of tumor cells (b, ×200) in model group. In cyclophosphamide group, patchy necrosis (c, ×200), the invasion into the muscle and fat and necrosis of tumor cells (d, ×200) were seen. Infiltration into fat and extensive necrosis (e, ×100) and apoptosis (f, ×200) of tumor cells was found in the Solanum nigrum polysaccharide (L) group. In addition, shrinking necrosis (g, ×200) of tumor cells and thymic cell proliferation (h, ×200) were found in the Solanum nigrum polysaccharide (M) group

Figure 3: Effect of <i>Solanum nigrum</i> polysaccharide on pathological changes in H and E staining. Forty mice bearing with H22 cells were randomly divided into four groups: model group, cyclophosphamide group (30 mg/kg), and <i>Solanum nigrum</i> polysaccharide groups with low and medium doses of <i>Solanum nigrum</i> polysaccharide (30, 60 mg/kg). A plenty of tumor cells and prominent nucleoli (a, ×400) and the infiltration into adipose tissue of tumor cells (b, ×200) in model group. In cyclophosphamide group, patchy necrosis (c, ×200), the invasion into the muscle and fat and necrosis of tumor cells (d, ×200) were seen. Infiltration into fat and extensive necrosis (e, ×100) and apoptosis (f, ×200) of tumor cells was found in the <i>Solanum nigrum</i> polysaccharide (L) group. In addition, shrinking necrosis (g, ×200) of tumor cells and thymic cell proliferation (h, ×200) were found in the <i>Solanum nigrum</i> polysaccharide (M) group