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Figure 2: Temozolomide and thymoquinone combination treatment. (a) Dose-effect curves for temozolomide, thymoquinone, and their combination after 72 h treatment. (b) Combination index plot: The combination index is plotted as a function of Fa. (c) Dose reduction index plot for combination: Dose reduction index values at different Fa values for each drug in the combination. (d) Isobologram for combination: Classic isobologram at IC50, IC75, and IC90

Figure 2: Temozolomide and thymoquinone combination treatment. (a) Dose-effect curves for temozolomide, thymoquinone, and their combination after 72 h treatment. (b) Combination index plot: The combination index is plotted as a function of Fa. (c) Dose reduction index plot for combination: Dose reduction index values at different Fa values for each drug in the combination. (d) Isobologram for combination: Classic isobologram at IC<sub>50</sub>, IC<sub>75</sub>, and IC<sub>90</sub>