Journal of Cancer Research and Therapeutics Close
 

Figure 7: Role of MMPs in cancer. MMPs contribute to the establishment of a conducive microenvironment for primary tumor growth, in tumor angiogenesis, and in the ability of tumor cells to migrate and invade into the surrounding stroma; in the breakdown of blood vessel basement membranes, which allows tumor cells entry into the circulation (intravasation) and exit from the circulation (extravasation); and in the modification of the distant site microenvironment, which allows growth of tumor cells by facilitating angiogenesis to the metastatic site

Figure 7: Role of MMPs in cancer. MMPs contribute to the establishment of a conducive microenvironment for primary tumor growth, in tumor angiogenesis, and in the ability of tumor cells to migrate and invade into the surrounding stroma; in the breakdown of blood vessel basement membranes, which allows tumor cells entry into the circulation (intravasation) and exit from the circulation (extravasation); and in the modification of the distant site microenvironment, which allows growth of tumor cells by facilitating angiogenesis to the metastatic site