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Figure 2: (a) Fine-needle aspiration cytology (FNAC) smear showing cellular clusters of the large cells of Langerhans cell histiocytosis (LCH) with prominent nuclear grooves (arrows) along with scattered lymphocytes and an occasional eosinophil (Papanicolaou stain, ×400). (b) Immunocytochemistry done on FNAC smear showing strongly positive nuclear and cytoplasmic expression of S-100 protein in the large cells of LCH (S-100 protein immunostain, × 400). (c) Diffuse sheets of the large cells of LCH admixed with osteoclastic-type giant cells, eosinophils, and lymphocytes (hematoxylin and eosin stain, ×400). (d ) Strong membranous expression of CD1a in the large cells of LCH (CD1a immunostain, × 400)

Figure 2: (a) Fine-needle aspiration cytology (FNAC) smear showing cellular clusters of the large cells of Langerhans cell histiocytosis (LCH) with prominent nuclear grooves (arrows) along with scattered lymphocytes and an occasional eosinophil (Papanicolaou stain, ×400). (b) Immunocytochemistry done on FNAC smear showing strongly positive nuclear and cytoplasmic expression of S-100 protein in the large cells of LCH (S-100 protein immunostain, × 400). (c) Diffuse sheets of the large cells of LCH admixed with osteoclastic-type giant cells, eosinophils, and lymphocytes (hematoxylin and eosin stain, ×400). (d ) Strong membranous expression of CD1a in the large cells of LCH (CD1a immunostain, × 400)