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Figure 4: Effects of CME-1 on the expression of phosphorylated (a) ERK1/2 and (b) p38 in B16F10 melanoma cell line. B16F10 (2×104) cells were treated with CME-1 (250, 500 and 800 μg/ml) for 30 mins. Cell lysates were obtained and analyzed for pERK1/2 and p38 proteins expression by Western blotting (bottom, densitometric analysis of bands for pERK1/2 and p38, relative to α-tubulin normalized to the untreated condition). *P < 0.05 and **P < 0.01 compared with the normal untreated B16 melanoma cells

Figure 4: Effects of CME-1 on the expression of phosphorylated (a) ERK1/2 and (b) p38 in B16F10 melanoma cell line. B16F10 (2×104) cells were treated with CME-1 (250, 500 and 800 μg/ml) for 30 mins. Cell lysates were obtained and analyzed for pERK1/2 and p38 proteins expression by Western blotting (bottom, densitometric analysis of bands for pERK1/2 and p38, relative to α-tubulin normalized to the untreated condition). *<i>P</i> < 0.05 and **<i>P</i> < 0.01 compared with the normal untreated B16 melanoma cells