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Figure 2: Kidney histology (H and E): (a) Control untreated rats: normal glomeruli and tubules × 200. (b) BME-treated rats: no pathological changes × 200. (c-d) Cisplatin-treated rats, (c) diffuse distortion of glomerular tufts with widening of Bowman's spaces (*) vacuolization, segmental dilation and atrophy of renal tubules (arrowheads), interstitial inflammatory infiltrate (arrow), ×200. (d) Proximal convoluted tubules with deeply eosinophilic cytoplasm and pyknotic nuclei (arrow), detachment of tubular epithelial cells, disruption of the luminal borders of renal tubular epithelial cells (arrowheads), intraluminal cellular debris and hyaline casts (*) ×200. (e-f) Cisplatin and BME co-treated rats, (e and f, ×100) no histological improvement of the glomerular and tubular pathology comparable to cisplatin group

Figure 2: Kidney histology (H and E): (a) Control untreated rats: normal glomeruli and tubules × 200. (b) BME-treated rats: no pathological changes × 200. (c-d) Cisplatin-treated rats, (c) diffuse distortion of glomerular tufts with widening of Bowman's spaces (*) vacuolization, segmental dilation and atrophy of renal tubules (arrowheads), interstitial inflammatory infiltrate (arrow), ×200. (d) Proximal convoluted tubules with deeply eosinophilic cytoplasm and pyknotic nuclei (arrow), detachment of tubular epithelial cells, disruption of the luminal borders of renal tubular epithelial cells (arrowheads), intraluminal cellular debris and hyaline casts (*) ×200. (e-f) Cisplatin and BME co-treated rats, (e and f, ×100) no histological improvement of the glomerular and tubular pathology comparable to cisplatin group