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Figure 1: Liver histology (H and E): (a) Control untreated rats: normal liver tissue, ×100. (b) BME-treated rats: congested central veins (*) and portal vein branch, ×100. Cisplatin-treated rats (c-e): (c) sinusoidal (*) and portal vein branch (arrowhead) congestion, and moderate portal mononuclear cell infiltration (arrow), ×200. (d) Spotty necrosis (arrowhead), disorganization of the hepatic cords (*), hepatocytes with pyknotic nuclei (arrow), and Kupffer cell hyperplasia × 200. (e) A well-formed granuloma (arrowhead) and many pyknotic nuclei (arrows) ×200. (f) Cisplatin and BME co-treated rats. Improvement of all pathological changes, however, marked ballooning of hepatocytes is seen × 100

Figure 1: Liver histology (H and E): (a) Control untreated rats: normal liver tissue, ×100. (b) BME-treated rats: congested central veins (*) and portal vein branch, ×100. Cisplatin-treated rats (c-e): (c) sinusoidal (*) and portal vein branch (arrowhead) congestion, and moderate portal mononuclear cell infiltration (arrow), ×200. (d) Spotty necrosis (arrowhead), disorganization of the hepatic cords (*), hepatocytes with pyknotic nuclei (arrow), and Kupffer cell hyperplasia × 200. (e) A well-formed granuloma (arrowhead) and many pyknotic nuclei (arrows) ×200. (f) Cisplatin and BME co-treated rats. Improvement of all pathological changes, however, marked ballooning of hepatocytes is seen × 100