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  Citation statistics : Table of Contents
   2006| October-December  | Volume 2 | Issue 4  
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"Nano": The new nemesis of cancer
Shantesh Hede, Nagraj Huilgol
October-December 2006, 2(4):186-195
DOI:10.4103/0973-1482.29829  PMID:17998702
Materials at nano dimensions exhibit totally different properties compared to their bulk and atomic states. This feature has been harnessed by scientists from various disciplines, to develop functional nanomaterials for cancer diagnosis and therapeutics. The success stories range from delivering chemotherapeutic molecules in nano-sized formulations to functional nanomaterials, which deliver thermal and radiotherapy at specific targeted sites. This brief review summarizes the recent developments of various nanotechnologies in cancer therapy and diagnostics, both from the research sector and the upcoming products in pipeline on its route to commercialization. Supportive engineering innovations and frontiers in nanomolecular research, with a potential to revolutionize cancer therapy, have been discussed in brief.
  25 56,513 2,870
Pathogenesis and treatment of gastric carcinoma: "An up-date with brief review"
Farhat Aziz Khan, Aditya Nath Shukla
October-December 2006, 2(4):196-199
DOI:10.4103/0973-1482.29830  PMID:17998703
Gastric cancer is one of the most common cancers and most frequent causes of cancer-related deaths in the world. The overall survival rate is 15-20%. Although the incidence is declining, its prognosis remains poor. The etiological factors and pathogenesis of gastric cancer are not yet fully understood. The integrated research in molecular pathology clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of development and progression of gastric cancer. Although epidemiological evidences indicate that environmental factors play a major role in the carcinogenesis, the role of immunological, genetic and immunogenetic factors are thought to contribute to etiopathogenesis of gastric carcinoma. In addition to better understanding of pathogenesis of gastric cancer, the incidence, diagnostic studies and the therapeutic options have also undergone important changes in the last decade. There is ongoing debate regarding the role of adjuvant treatment. In advanced disease, palliation of symptoms, rather than cure, is the primary goal of patient management. Several combination therapies have been developed and have been examined in phase III trials; however, in most cases, they have failed to demonstrate a survival advantage over the reference arm. This review summarizes the newer concepts of molecular biology on gastric carcinogenesis and the new important recommendations for the management of patient with gastric carcinoma.
  22 16,637 2,166
Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction
A Szasz, Gy. Vincze
October-December 2006, 2(4):171-181
DOI:10.4103/0973-1482.29827  PMID:17998700
We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.
  16 22,871 870
Recurrent episodes of hematuria: A rare presentation of leiomyosarcoma of prostate
Kaustav Talapatra, Bhushan Nemade, Ritu Bhutani, Shubhada Kane, Ashish Bakshi, Mary Ann Muckaden, Siddhartha Laskar
October-December 2006, 2(4):212-214
DOI:10.4103/0973-1482.29837  PMID:17998709
Leiomyosarcoma of the prostate is an extremely rare entity. Sarcomas account for about 1% of all malignant tumors and less than 5% of them arise from the genitourinary tract. Majority of patients present with urinary obstructive symptoms. The outcome is generally poor. Surgery with or without radiotherapy / chemotherapy forms the mainstay of treatment for patients with operable tumors. We report a patient presenting with recurrent episodes of hematuria.
  7 7,646 376
Paraneoplastic leukocytoclastic vasculitis in chronic lymphoid leukemia
BS Yadav, SC Sharma, RK Kapoor
October-December 2006, 2(4):206-208
DOI:10.4103/0973-1482.29835  PMID:17998707
A 50-year-old female who was a known case of chronic lymphoid leukemia (CLL) developed ecchymoses, purpuric spots with papules, some nodules (1-3 mm) and crusts all over the body associated with severe burning and itching along with exaggeration of CLL. The lesions were more prominent on lower limbs and face. Skin biopsy was reported as leukocytoclastic vasculitis. These lesions regressed after treatment with leukeran and glucocorticoids.
  6 11,740 550
Intensity modulated radiotherapy in abdominal malignancies: Our experience in reducing the dose to normal structures as compared to the gross tumor
Tejinder Kataria, Sheh Rawat, SN Sinha, PS Negi, Charu Garg, NK Bhalla, RK Munjal
October-December 2006, 2(4):161-165
DOI:10.4103/0973-1482.29825  PMID:17998698
Background and Purpose: A better understanding of appropriate sequencing and use of multimodality approach in the management and subsequent improvement in overall survival mandates a vigil on quality of life issues. Intensity modulated radiotherapy (IMRT) is a powerful tool, which might go a long way in reducing radiation doses to critical structures and thereby reduce long term morbidities. The purpose of this paper is to evaluate the impact of IMRT in reducing the dose to the critical normal tissues while maintaining the desired dose to the volume of interest for abdominal malignancies. Materials and Methods: During the period January 2002 to March 2004, 11 patients of various sites of malignancies in the abdominal region were treated using physical intensity modulator based IMRT. Plans of these patients treated with IMRT were analyzed using dose volume histograms. Results: An average dose reduction of the mean values by 50% to the liver, 57% to the right kidney, 56% to the left kidney, 66% to the cord and 27% to the bowel, with respect to the GTV could be achieved with IMRT. The two-year disease free survival was 79% and two-year overall survival was 88%. The average number of IMRT fields used was six. Conclusion: IMRT with inverse planning enabled us to achieve desired dose distribution, due to its ability to provide sharp dose gradients at the junction of tumor and the adjacent critical organs.
  6 5,769 433
Adult paratesticular malignant fibrous histiocytoma treated with surgery, systemic chemotherapy and postoperative adjuvant radiotherapy
Gilbert DA Padula, Matthew Schmitz
October-December 2006, 2(4):201-202
DOI:10.4103/0973-1482.29832  PMID:17998705
Paratesticular malignant fibrous histiocytoma is an extremely rare malignancy of the scrotum. This malignancy has rarely been described in the literature and scant information exists on the optimal management of this cancer. We present here a case of a 57-year-old man with a diagnosis of high-grade malignant fibrous histiocytoma of the left intrascrotal region who underwent radical orchiectomy, systemic chemotherapy and postoperative radiotherapy.
  3 4,962 311
A decade of discovery of BRCA1 and BRCA2: Are we turning the tide against hereditary breast cancers?
Rajiv Sarin
October-December 2006, 2(4):157-158
DOI:10.4103/0973-1482.29823  PMID:17998696
  3 12,128 1,002
Translation and pilot validation of Hindi translation of assessing quality of life in patients with primary brain tumours using EORTC brain module (BN-20)
Ashwini Budrukkar, Rakesh Jalali, Rashmi Kamble, Sachin Parab
October-December 2006, 2(4):166-170
DOI:10.4103/0973-1482.29826  PMID:17998699
Aim: To translate and validate the European Organisation for Research and Treatment for Cancer (EORTC) brain cancer module (BN-20) into Hindi to make it available for patients and scientific community. Methods and Results: The EORTC BN-20 was translated into Hindi using standard guidelines by EORTC. The process included forward translation by two translators, discussion with the translators in case of discrepancies and formation of first intermediate questionnaire. This questionnaire was then given to two more translators who translated this questionnaire back into English. These 2 questionnaires were then compared with the original EORTC questionnaire and the second intermediate questionnaire was formed. The second intermediate questionnaire was subsequently administered in 10 patients with brain tumors who had never seen the questionnaire before, for pilot-testing. Each of these 10 patients after filling up the questionnaire themselves was then interviewed for any difficulty encountered during the filling up of the questionnaire. These were in the form of specific modules including difficulty in answering, confusion while answering and difficulty to understand, whether the questions were upsetting and if patients would have asked the question in any different way. There were major suggestions in three questions, which were incorporated into the second intermediate questionnaire to form the final Hindi BN-20 questionnaire. Conclusion: The final Hindi BN-20 has been approved by EORTC and can be used in clinical practice and studies for patients with brain tumors.
  3 9,689 478
Sweat gland carcinoma with lung metastases
Amit Bahl, DN Sharma, PK Julka, Anup Das, GK Rath
October-December 2006, 2(4):209-211
DOI:10.4103/0973-1482.29836  PMID:17998708
Sweat gland carcinoma is a rare skin tumor. The tumor has propensity to spread to lymph nodes and distant metastases has been reported. Their exact incidence in the Indian setting is not known. Aspects related to treatment are also not clearly defined. Though surgery forms the initial treatment approach, adjuvant treatment has not been properly explored. We report here a case of sweat gland carcinoma with bilateral lung metastases.
  2 9,404 378
Current substance use in patients with gastric cancer in Southern Iran
SZ Tabei, ST Heydari, D Mehrabani, SJ Shamsina, J Ahmadi, Saberi M Firouzi
October-December 2006, 2(4):182-185
DOI:10.4103/0973-1482.29828  PMID:17998701
Background: Psychiatric disorders may affect patients suffering from cancer and substance use disorders. Objective: This study was undertaken to evaluate the prevalence of tobacco and opioid use in patients with gastric cancer in Shiraz, Fars Province and Southern Iran. Materials and Methods: In a hospital survey of 177 gastric cancer patients aged 24 years and more, a semistructured-interview was performed based on SDM-IV criteria during the year 2003. Results: The mean age of the patients was 58.13 (SD=14.03) years. Among the subjects, 50.9% (90) were tobacco dependent (61.5% men and 29.4% women, P <0.001), while 10 (5.7%) were opioid-dependent (7.3% men and 1.9% women, P =0.16). Tobacco and opioid-dependency were not significantly related to age groups, economical or occupational status. Mean ages of tobacco and opioid-dependants were not significantly different from nondependants. Conclusions: Tobacco and opioid dependency were common problems among gastric cancer patients. This report provides useful information for health planning. Men were at greater risk than women. Treatment programs should focus on all age-groups, all occupations and all income-levels.
  2 7,433 353
B cell lymphoma with unusual clinical cutaneaous presentation
Satyabrata Dasgupta, Debabrata Mitra, Aparna Bhattacharya, Prabir K Sur
October-December 2006, 2(4):203-205
DOI:10.4103/0973-1482.29834  PMID:17998706
Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin. These are rarer than T cell lymphomas. Commonly, the presenting features of CBCL are plaques or nodules. Here is a case report of CBCL with a very unusual presentation of cutaneous horns. The patient was managed by a combination chemotherapy and local radiotherapy only. He is disease-free for about the last five years. The case has been presented because of its rarity and its management protocol.
  1 5,091 364
Squamous cell carcinoma over a nevus: A rare case
KC Patro, S Padhi, DN Singh
October-December 2006, 2(4):200-200
DOI:10.4103/0973-1482.29831  PMID:17998704
Malignant melanoma and basal cell carcinoma are more common over a preexisting nevus. But squamous cell carcinoma over a nevus is a rare phenomenon. A 55-year-old male presented with a slow growing noduloulcerative lesion on a preexisting nevus over scalp. For that he had undergone excisional biopsy. Biopsy came out to be a squamous cell carcinoma with lateral margin positive for tumor. So postoperative radiotherapy given by means of HDR brachytherapy. Now he is on follow-up.
  - 4,012 256
'Bust that noma'
Rakesh Jalali, Ruchi Narain
October-December 2006, 2(4):216-217
  - 3,417 164
Advances in radiation oncology: Time to move ahead
GK Rath, DN Sharma, Amit Bahl
October-December 2006, 2(4):159-160
DOI:10.4103/0973-1482.29824  PMID:17998697
  - 4,259 308