Year : 2021 | Volume
: 17 | Issue : 1 | Page : 51--55
Outcomes of patients with anal cancer treated with volumetric-modulated arc therapy or intensity-modulated radiotherapy and concurrent chemotherapy
Serap Yucel1, Huseyin Kadioglu2, Zeynep Gural1, Zuleyha Akgun3, Esra Kaytan Saglam4
1 Department of Radiation Oncology, Acibadem University, Istanbul, Turkey
2 Department of General Surgery, Faculty of Medical, Bezmialem University, Istanbul, Turkey
3 Department of Radiation Oncology, Memorial Hospital, Istanbul, Turkey
4 Department of Radiation Oncology, Istanbul University Medical Faculty, Istanbul, Turkey
Aims: To evaluate the results of chemoradiation with intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT) for the treatment of anal canal cancer patients at three institutions that had advanced devices.
Materials and Methods: A retrospective analysis was performed for patients treated with 5-fluorouracil and mitomycin-based chemotherapy and IMRT or VMAT for anal cancer from 2011 to 2013. Complete response (CR) rates, colostomy-free survival (CFS), disease-free survival (DFS), overall survival (OS), and toxicities were investigated. Toxicities were evaluated with the Common Terminology Criteria for Adverse Events, Version 3.0.
Results: Fifteen patients were included in the analysis. The majority of patients had T2 (53.3%) and N0 (40%) disease according to the staging system that was developed by the American Joint Committee on Cancer. CR was observed in 14 patients (93%), and the median follow-up was 26 months (13–42 months). The 3-year CFS, DFS, and OS were 86%, 86%, and 88%, respectively. Acute Grade 3 toxicities were observed as 6% of hematological, 26% of gastrointestinal, and 26% of dermatological.
Conclusion: Early results confirm that IMRT or VMAT for anal cancer treatment reduces acute toxicities while maintaining high control rates.
Department of Radiation Oncology, Acibadem University, Istanbul
|How to cite this article:|
Yucel S, Kadioglu H, Gural Z, Akgun Z, Saglam EK. Outcomes of patients with anal cancer treated with volumetric-modulated arc therapy or intensity-modulated radiotherapy and concurrent chemotherapy.J Can Res Ther 2021;17:51-55
|How to cite this URL:|
Yucel S, Kadioglu H, Gural Z, Akgun Z, Saglam EK. Outcomes of patients with anal cancer treated with volumetric-modulated arc therapy or intensity-modulated radiotherapy and concurrent chemotherapy. J Can Res Ther [serial online] 2021 [cited 2021 May 9 ];17:51-55
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2021;volume=17;issue=1;spage=51;epage=55;aulast=Yucel;type=0