Journal of Cancer Research and Therapeutics

REVIEW ARTICLE
Year
: 2021  |  Volume : 17  |  Issue : 1  |  Page : 22--28

Oxidative stress and its role in cancer


Marija Dragan Jelic1, Aljosa D Mandic2, Slobodan M Maricic2, Branislava U Srdjenovic1 
1 University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia
2 University of Novi Sad, Faculty of Medicine; Oncology Institute of Vojvodina, Sremska Kamenica, Novi Sad, Serbia

Correspondence Address:
Marija Dragan Jelic
Master of Parmacy, Hajduk Veljkova 3, 21000 Novi Sad
Serbia

Reactive oxygen species (ROS) can damage lipids, nucleic acids, and proteins, thereby altering their functions. When a balance between production of ROS and antioxidative defense is disturbed, state of oxidative stress occurs. Oxidative stress leads to many diseases. There are few biomarkers that are used for better understanding how oxidative stress is involved in cancer pathophysiology. This review focuses on 8-hidroxy-2-deoxyguanosine (8-OHdG) and antioxidative enzymes as biomarkers for measurement of oxidative stress in different types of cancer. This review also deals with the product of lipid peroxidation, malondialdehyde (MDA), and across a variety of cancers. To address this aim, analysis of studies of breast, prostate, lung, colon, cervical, ovarian, brain, bladder, renal, thyroid cancer, and chronic lymphocytic leukemia has been conducted. In general, levels of antioxidative enzymes are mostly lower in cancer patients, while 8-OHdG and MDA are higher. Further research is needed, with focus on correlation levels of these biomarkers and advancement of the disease. Moreover, all studies explored the idea of those biomarkers as a useful tool in determining the levels of oxidative stress. Some of the studies proposed their potential in defining the stage of tumor progression.


How to cite this article:
Jelic MD, Mandic AD, Maricic SM, Srdjenovic BU. Oxidative stress and its role in cancer.J Can Res Ther 2021;17:22-28


How to cite this URL:
Jelic MD, Mandic AD, Maricic SM, Srdjenovic BU. Oxidative stress and its role in cancer. J Can Res Ther [serial online] 2021 [cited 2021 Jun 20 ];17:22-28
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2021;volume=17;issue=1;spage=22;epage=28;aulast=Jelic;type=0