Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 5  |  Page : 1165--1170

Transcatheter arterial chemoembolization combined with low-dose apatinib in the treatment of unresectable hepatocellular carcinoma in elderly patients: Efficacy and safety


Song Liu1, Guangsheng Zhao2, Guangji Yu3, Nannan Guo4, Yuewei Zhang5, Qiang Li3, Zhe Wang7 
1 Department of Interventional Therapy, Linyi Cancer Hospital, Linyi; Affiliated provincial hospital, Shandong University School of Clinical Medicine, Jinan, Shandong Province, China
2 Hepatobiliary and Pancreatic Center, Beijing Tsinghua Changgeng Hospital, Changping District, Beijing; Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China
3 Department of Interventional Therapy, Linyi Cancer Hospital, Linyi, Shandong Province, China
4 Department of Oncology, Binzhou People's Hospital, Binzhou, Shandong Province, China
5 Hepatobiliary and Pancreatic Center, Beijing Tsinghua Changgeng Hospital, Changping District, Beijing, China

Correspondence Address:
Qiang Li
Department of Interventional Therapy, Linyi Cancer Hospital, No. 6 East Lingyuan Street, Linyi 276001, Shandong Province
China
Zhe Wang
Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian 116001, Liaoning Province
China

Context: Owing to the increasing age of the population, the incidence of hepatocellular carcinoma (HCC) in the elderly is increasing annually. Aims: This study aims to investigate the clinical efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with low-dose apatinib for unresectable HCC treatment in elderly patients (≥65 years). Settings and Design: The clinical data from 61 elderly patients with unresectable HCC who were retrospectively analyzed. Subjects and Methods: Of these 61 patients, 27 received TACE combined with low-dose (250 mg/qd) apatinib (experimental group), and 34 patients received the standard TACE treatment (control group). The short-term efficacy was evaluated according to the mRECIST1.1 standards, and the mid- and long-term efficacy and safety in the two groups of patients were evaluated. Statistical Analysis Used: Statistical analyses were performed using the Statistical Package for the Social Sciences software (version 20.0; SPSS). Results: Both the objective response rate and disease control rate of the experimental group were significantly higher than those of control group (P < 0.05). The 6-month and 12-month survival rates of the experimental group were significantly higher than those of control group too (P < 0.05). The median survival in the experimental group was longer than in the control group (26.0 months vs. 20.0 months). The adverse reactions related to the intake of apatinib were higher in the experimental than the control group, but were generally alleviated after symptomatic treatment. Conclusions: TACE combined with low-dose apatinib provides an alternative treatment option for elderly patients with unresectable HCC. Our clinical study has proven its safety and efficacy.


How to cite this article:
Liu S, Zhao G, Yu G, Guo N, Zhang Y, Li Q, Wang Z. Transcatheter arterial chemoembolization combined with low-dose apatinib in the treatment of unresectable hepatocellular carcinoma in elderly patients: Efficacy and safety.J Can Res Ther 2020;16:1165-1170


How to cite this URL:
Liu S, Zhao G, Yu G, Guo N, Zhang Y, Li Q, Wang Z. Transcatheter arterial chemoembolization combined with low-dose apatinib in the treatment of unresectable hepatocellular carcinoma in elderly patients: Efficacy and safety. J Can Res Ther [serial online] 2020 [cited 2020 Nov 24 ];16:1165-1170
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=5;spage=1165;epage=1170;aulast=Liu;type=0