Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 5  |  Page : 1038--1050

Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation


Qi Yang1, Xiao-ling Yu1, Ying Wang2, Zhi-gang Cheng1, Zhi-yu Han1, Fang-yi Liu1, Tong-gang Qian3, Jie Yu1, Ping Liang1 
1 Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China
2 Department of Ultrasound, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, China
3 Department of Ultrasound, Zunhua People's Hospital, Hebei Province, Zunhua 064200, China

Correspondence Address:
Jie Yu
Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853
China
Ping Liang
Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853
China
Tong-gang Qian
Department of Ultrasound, Zunhua People's Hospital, Hebei Province, Zunhua 064200
China

Aim: This study aimed to investigate the predictive power of the combination of Systemic Immune-Inflammation Index (SII) and albumin-bilirubin (ALBI) grade in prognosis outcomes of early-stage hepatocellular carcinoma (HCC) after thermal ablation. Materials and Methods: This retrospective study was reviewed and approved by our institutional review board, and written informed consent was obtained from each patient. According to the Milan criteria, a total of 405 treatment-naïve patients with clinicopathologically confirmed HCC were enrolled who subsequently underwent thermal ablation from 2011 to 2016. The outcomes of overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were statistically analyzed. Results: The median follow-up time of this study was 45.1 months (range, 1.3–83.2 months). After thermal ablation in patients with SII-ALBI Grades 1, 2, and 3, the cumulative 5-year OS rates were 81.7%, 63.2%, and 26.9%; the 5-year CSS rates were 82.4%, 67.5%, and 26.9%; and the 5-year RFS rates were 49.3%, 44.6%, and 25.3%, respectively (all P < 0.001). On multivariate Cox regression analyses, SII-ALBI was independently associated with the three outcomes after adjustment for various confounders (all P < 0.05). In addition, SII-ALBI played a predictive role in OS, CSS, and RFS for patients with negative alpha-fetoprotein (AFP) (P < 0.05). Compared with SII and ALBI, the AUCs for the prediction of OS and CSS using SII-ALBI were superior to single indicator (bothP < 0.05). Conclusion: Elevated preablation SII-ALBI is associated with shorter OS, CSS, and RFS in patients with early-stage HCC. Our indicator showed the potential to be a supplement tool for patients with negative AFP during follow-up.


How to cite this article:
Yang Q, Yu Xl, Wang Y, Cheng Zg, Han Zy, Liu Fy, Qian Tg, Yu J, Liang P. Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation.J Can Res Ther 2020;16:1038-1050


How to cite this URL:
Yang Q, Yu Xl, Wang Y, Cheng Zg, Han Zy, Liu Fy, Qian Tg, Yu J, Liang P. Predictive effects of a combined indicator in patients with hepatocellular carcinoma after thermal ablation. J Can Res Ther [serial online] 2020 [cited 2021 May 7 ];16:1038-1050
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=5;spage=1038;epage=1050;aulast=Yang;type=0