Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 8  |  Page : 76--81

Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?


Ibrahim Aydogdu1, Yusuf Ozlem Ilbey2, Ganime Coban3, Rahmi Gokhan Ekin1, Semih Lutfi Mirapoglu1, Ali Cay1, Huriye Senay Kiziltan4, Zubeyde Yildirim Ekin5, Mesrur Selcuk Silay6, Mehmet Bulent Semerci7 
1 Department of Pediatric Surgery, Bezmialem Vakif University, Istanbul, Turkey
2 Department of Urology, Tepecik Teaching and Research Hospital, Izmir, Turkey
3 Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey
4 Department of Radiation Oncology, Bezmialem Vakif University, Istanbul, Turkey
5 Department of Pathology, Ege University, Izmir, Turkey
6 Department of Urology, Medeniyet University, Istanbul, Turkey
7 Department of Urology, Ege University, Izmir, Turkey

Correspondence Address:
Prof. Rahmi Gokhan Ekin
Department of Urology, Tepecik Teaching and Research Hospital, Gaziler Caddesi, 35000, Yenisehir, Izmir
Turkey

Objective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)-induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation-induced testicular damage. OT may be beneficial to the patients who underwent RT.


How to cite this article:
Aydogdu I, Ilbey YO, Coban G, Ekin RG, Mirapoglu SL, Cay A, Kiziltan HS, Ekin ZY, Silay MS, Semerci MB. Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?.J Can Res Ther 2019;15:76-81


How to cite this URL:
Aydogdu I, Ilbey YO, Coban G, Ekin RG, Mirapoglu SL, Cay A, Kiziltan HS, Ekin ZY, Silay MS, Semerci MB. Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?. J Can Res Ther [serial online] 2019 [cited 2021 Jan 17 ];15:76-81
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2019;volume=15;issue=8;spage=76;epage=81;aulast=Aydogdu;type=0