Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 15  |  Issue : 8  |  Page : 60--68

Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis


Jiaxuan Qin1, Ni Cui2, Ruida Hou1, Tie Liu3, Hongyan Sun3, Yi Liu3, Lei Wang3, Jinsong Ni4, Xinquan Gu1 
1 Department of Urology Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
2 Department of Clinical Medicine, Bethune Medical School, Jilin University, Changchun, Jilin, China
3 Department of Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
4 Department of Pathology, The First Clinical Hospital of Jilin University, Changchun, Jilin, China

Correspondence Address:
Prof. Xinquan Gu
Department of Urology Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin
China

Objective: To estimate association between androgen receptor (AR) gene polymorphisms and testicular germ cell tumor (TGCT) susceptibility. Materials and Methods: Systematic search of studies on the association between AR gene polymorphisms and TGCT susceptibility was conducted. Odds ratios and 95% confidence intervals were used to pool effect size. Results: For CAG repeat, no evidence was found for association between (>25 vs. ≤25), (>25 vs. 21–25), (<21 vs. 21–25), (others vs. 21–25), (>23 vs. ≤23), (<21 vs. ≥21), (<21 vs. ≥21)'s some subgroups and TGCT susceptibility, which showed stability. In (>24 vs. ≤24), (>24 vs. 21–24), (<21 vs. 21–24), and (others vs. 21–24) and almost all of their subgroups, increased TGCT risk was found without sensitivity analysis. For GGN, no statistical change of TGCT risk was found in (<23 vs. ≥23), (<23 vs. 23), which showed stability. For single nucleotide polymorphism (SNP) rs6152 G > A, rs1204038 G > A and rs2361634 A > G, no statistical change was found without sensitivity analysis. Conclusions: GGN repeat number <23 may not be associated with TGCTs susceptibility. However, there was insufficient data to fully confirm association in GGN repeat number >23, CAG repeat number, SNP rs6152, rs1204038, and rs2361634.


How to cite this article:
Qin J, Cui N, Hou R, Liu T, Sun H, Liu Y, Wang L, Ni J, Gu X. Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis.J Can Res Ther 2019;15:60-68


How to cite this URL:
Qin J, Cui N, Hou R, Liu T, Sun H, Liu Y, Wang L, Ni J, Gu X. Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis. J Can Res Ther [serial online] 2019 [cited 2021 Jan 28 ];15:60-68
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2019;volume=15;issue=8;spage=60;epage=68;aulast=Qin;type=0