Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 8  |  Page : 100--104

Effect of spleen tyrosine kinase on nonsmall cell lung cancer


Ying Tao Hao, Chuan Liang Peng, Yun Peng Zhao, Qi Feng Sun, Xiao Gang Zhao, Bo Cong 
 Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China

Correspondence Address:
Bo Cong
Department of Thoracic, The Second Hospital of Shandong University, 247, Beiyuan Street, Jinan 250033, Shandong
China

Aim of Study: To investigate the anti.tumor effect of spleen tyrosine kinase. (Syk) on the human nonsmall cell lung cancer cells in vitro and its mechanism. Materials and Methods: In this study, we constructed a eukaryotic expression vector pcDNA3.1D/V5-His-TOPO/Syk and transfected it into human nonsmall cell lung cancer cells A549. Then, we not only analyzed the expression of Syk in transfected cells and its invasion but also the expression of matrix metalloproteinase-9 (MMP-9). Results: The results showed that overexpressed Syk significantly inhibited A549 cell invasive ability by decreasing the expression of MMP-9. Conclusion: The overexpressed Syk plays an important role in tumor invasion and metastasis, and a negative role in human nonsmall cell lung cancer cells.


How to cite this article:
Hao YT, Peng CL, Zhao YP, Sun QF, Zhao XG, Cong B. Effect of spleen tyrosine kinase on nonsmall cell lung cancer.J Can Res Ther 2018;14:100-104


How to cite this URL:
Hao YT, Peng CL, Zhao YP, Sun QF, Zhao XG, Cong B. Effect of spleen tyrosine kinase on nonsmall cell lung cancer. J Can Res Ther [serial online] 2018 [cited 2022 Jan 21 ];14:100-104
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=8;spage=100;epage=104;aulast=Hao;type=0