Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 2  |  Page : 314--320

The effects of gilaburu (Viburnum opulus) juice on experimentally induced Ehrlich ascites tumor in mice


Dilek Ceylan1, Ahmet Aksoy2, Tolga Ertekin3, Arzu Hanım Yay4, Mehtap Nisari3, Gökçe Şeker Karatoprak5, Harun Ülger3 
1 Genome and Stem Cell Center, University of Erciyes, Kayseri, Turkey
2 Department of Biology, School of Arts and Sciences, University of Akdeniz, Antalya, Turkey
3 Department of Anatomy, School of Medicine, University of Erciyes, Kayseri, Turkey
4 Department of Histology and Embryology, School of Medicine, University of Erciyes, Kayseri, Turkey
5 Department of Pharmacognosis, School of Pharmacy, University of Erciyes, Kayseri, Turkey

Correspondence Address:
Dr. Dilek Ceylan
Genome and Stem Cell Center, University of Erciyes, Kayseri 38039
Turkey

Objective: The aim of study was to investigate anticancer effect of Viburnum opulus (VO) on Ehrlich ascites carcinoma (EAC) bearing mice that treated with different concentrations of VO. Materials and Methods: For tumor transplantation; mice were inoculated with 1 × 106 EAC cells intraperitoneally and than divided into five groups (n = 9). Two hours after inoculation; experimental groups were treated daily with VO extract at doses of 1000 mg/kg, 2000 mg/kg, 4000 mg/kg. Results: Extracts obtained from gilaburu juice can have hinder effect on tumor cell growth. Conclusion: As far as we known, this is the first study about in vivo antitumoral activity of VOon Ehrlich ascites tumor model, and consequently VO extract exhibited anticancer activity against EAC-bearing mice.


How to cite this article:
Ceylan D, Aksoy A, Ertekin T, Yay AH, Nisari M, Karatoprak G&, Ülger H. The effects of gilaburu (Viburnum opulus) juice on experimentally induced Ehrlich ascites tumor in mice.J Can Res Ther 2018;14:314-320


How to cite this URL:
Ceylan D, Aksoy A, Ertekin T, Yay AH, Nisari M, Karatoprak G&, Ülger H. The effects of gilaburu (Viburnum opulus) juice on experimentally induced Ehrlich ascites tumor in mice. J Can Res Ther [serial online] 2018 [cited 2020 Nov 28 ];14:314-320
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=2;spage=314;epage=320;aulast=Ceylan;type=0