Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 1  |  Page : 133--138

Efficacy and safety of epirubicin applied in transcatheter arterial chemoembolization for hepatocellular carcinoma: A meta-analysis


Zhibin Bai, Yonglin Qin, Guangyu Zhu, Guofeng Zhao, Gang Deng, Jinhe Guo, Shicheng He 
 Department of Interventional Radiology and Vascular Surgery, Zhongda Hospital of Southeast University, Nanjing, Jiangsu Province, People's Republic of China

Correspondence Address:
Dr. Zhibin Bai
Department of Interventional Radiology and Vascular Surgery, Zhongda Hospital of Southeast University, Dingjiaqiao 87, Nanjing, Jiangsu Province 210009
People's Republic of China

Objectives: This study was aimed to evaluate the efficacy and safety of epirubicin applied in transcatheter arterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). Materials and Methods: Studies were searched in Embase, PubMed, and Springer until August 10, 2016. All the studies were screened with inclusion and exclusion criteria. The quality assessment of the eligible studies was performed with the Newcastle-Ottawa Scale and the Jadad Scale. Response rate, recurrence, mortality, and thrombocytopenia were evaluated with risk ratios (RRs) with 95% confidence intervals (CIs). The heterogeneity and publication bias were assessed. Results: Ten eligible studies were included with a total of 993 objects. The data were extracted and summarized. The overall results were calculated including response rate (RR = 0.98, 95% CI: 0.83–1.15), recurrence (RR = 0.75, 95% CI: 0.58–0.96), mortality (RR = 0.71, 95% CI: 0.39–1.28), and thrombocytopenia (RR = 0.42, 95% CI: 0.09–1.93), without significant heterogeneity. There was a significant heterogeneity for mortality; thus, the random effects model was used. No publication bias was observed in this study. Conclusions: The results of meta-analysis indicated that epirubicin applied in TACE has an obvious efficacy for the treatment of HCC, with significantly decreased recurrence while without superiority of safety.


How to cite this article:
Bai Z, Qin Y, Zhu G, Zhao G, Deng G, Guo J, He S. Efficacy and safety of epirubicin applied in transcatheter arterial chemoembolization for hepatocellular carcinoma: A meta-analysis.J Can Res Ther 2018;14:133-138


How to cite this URL:
Bai Z, Qin Y, Zhu G, Zhao G, Deng G, Guo J, He S. Efficacy and safety of epirubicin applied in transcatheter arterial chemoembolization for hepatocellular carcinoma: A meta-analysis. J Can Res Ther [serial online] 2018 [cited 2020 Nov 24 ];14:133-138
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=1;spage=133;epage=138;aulast=Bai;type=0