Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 14  |  Issue : 10  |  Page : 719--723

Survivin expression as an independent predictor of overall survival in pancreatic adenocarcinoma


John Contis1, Panagis M Lykoudis1, Kallirroi Goula2, Despoina Karandrea2, Agathi Kondi-Pafiti2 
1 2nd Department of Surgery, Aretaieio University Hospital, National and Kapodistrian University of Athens, Athens, Greece
2 Department of Pathology, Aretaieio University Hospital, National and Kapodistrian University of Athens, Athens, Greece

Correspondence Address:
Panagis M Lykoudis
2nd Department of Surgery, Aretaieio University Hospital, 75, Vas. Sofias Ave., Athens, 11528
Greece

Context: Survivin is an antiapoptotic protein with a role in tumorigenesis and suggested prognostic value in several proliferative diseases. Aims: This study aimed to examine the role of survivin as a prognostic marker in pancreatic adenocarcinoma (PDAC). Settings and Design: Fifty-one specimens of PDAC were assessed for survivin expression by immunohistochemistry. Subjects and Methods: Overall survival and 1-, 3-, and 5-year survival were retrieved retrospectively. Statistical Analysis Used: Bivariate analysis was conducted using Chi-square and Mann–Whitney U tests, while survival analysis was conducted using Kaplan–Meier statistics. Results: Of the 51 assessed cases, 49% were positive for survivin. Survivin expression was significantly correlated 1-year survival and overall survival, particularly in bcl-2 positive cases. Conclusions: Survivin may be implicated in the bcl-2 and p53 pathways and therefore in the biology of PDAC. Its potential use as a survival predictor and therapeutic target represent a promising field.


How to cite this article:
Contis J, Lykoudis PM, Goula K, Karandrea D, Kondi-Pafiti A. Survivin expression as an independent predictor of overall survival in pancreatic adenocarcinoma.J Can Res Ther 2018;14:719-723


How to cite this URL:
Contis J, Lykoudis PM, Goula K, Karandrea D, Kondi-Pafiti A. Survivin expression as an independent predictor of overall survival in pancreatic adenocarcinoma. J Can Res Ther [serial online] 2018 [cited 2022 Jun 26 ];14:719-723
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=10;spage=719;epage=723;aulast=Contis;type=0