Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 12  |  Issue : 8  |  Page : 291--294

Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics


Debiao Pan, Shi Wang, Hailin Ye, Shengqian Xu, Guanxiong Ye 
 Department of General Surgery, Lishui People's Hospital, Lishui, Zhejiang, P.R. China

Correspondence Address:
Shi Wang
Department of General Surgery, Lishui People's Hospital, Lishui, Zhejiang 323000
P.R. China

Objective: The aim of this study was to assess Ezrin expression in the primary hepatic carcinoma patients and associated with clinical, pathological characteristics. Materials and Methods: Fifty-one patients with primary hepatocellular carcinoma (PHC) with completed clinical data were retrospectively analyzed in this study. The Ezrin expression in PHC and normal control liver tissue was tested by immunohistochemical assay. The Ezrin expression and relationship with clinical characteristics were evaluated. Results: The Ezrin positive rate were 66.7% and 15.7% with expression score of 3.21 ± 1.46 and 0.60 ± 1.10, respectively, in the cancer tissue and control tissue with statistical difference (P < 0.05). The Ezrin expression was associated with the metastasis status of the patients (P < 0.05) but not associated with the age (P > 0.05), gender (P > 0.05), differentiation (P > 0.05), and tumor diameter (P > 0.05). Conclusion: Ezrin protein is highly expressed in human PHC tissue which can be used for the prediction of metastasis disease.


How to cite this article:
Pan D, Wang S, Ye H, Xu S, Ye G. Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics.J Can Res Ther 2016;12:291-294


How to cite this URL:
Pan D, Wang S, Ye H, Xu S, Ye G. Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics. J Can Res Ther [serial online] 2016 [cited 2021 Sep 23 ];12:291-294
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2016;volume=12;issue=8;spage=291;epage=294;aulast=Pan;type=0