Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 11  |  Issue : 8  |  Page : 244--247

Combined use of radioiodine therapy and radiofrequency ablation in treating postsurgical thyroid remnant of differentiated thyroid carcinoma


Bin Long1, Linfa Li1, Lifang Yao1, Shoucong Chen1, Heqing Yi1, Xuemei Ye1, Dong Xu2, Peng Wu3 
1 Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, People's Republic of, China
2 Department of Ultrasonography, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, People's Republic of, China
3 Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, People's Republic of, China

Correspondence Address:
Linfa Li
Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022
China

Purpose: To determine whether postoperative radioiodine (RAI) combined with radiofrequency ablation (RFA) is an effective, safe, and feasible method for elimination of excessive postsurgical thyroid remnant for differentiated thyroid carcinoma (DTC). Materials and Methods: We took a prospective study and treated 12 DTC patients (4 males, 8 females, age 20–78 years) who underwent thyroidectomy for RFA followed by 131 I ablation. The pretreatment requires iodine-free diet and thyroid hormone withdrawal for 3–4 week. All the patients showed the level of serum thyroid-stimulating hormone (TSH) <30 mU/L, and obvious thyroid remnant in 99m Technetium (99m Tc) imaging. Serum TSH level was determined 1 day before RFA and on days 1, 7, 14 after RFA, and 99m Tc imaging was performed on day 14 after RFA. Subsequently, the patients were given an oral dosage of 3700 MBq 131 I for remnant ablation, and posttreatment whole body scan was performed on day 5 after ablation. Efficacy evaluation was done 4–6 months after treatment. The changes of variants before and after RFA were analyzed using Wilcoxon signed rank sum test. Results: Serum TSH was <30 μIU/ml (mean value 10.27 ± 6.16 μIU/ml) before RFA, and increased to more than 30 μIU/ml (34.73 ± 3.93 μIU/ml) 2 weeks later (P = 0.002, Wilcoxon rank sum test). The 99m Tc uptake ratio on day 14 postRFA was (0.31 ± 0.12)%, which is significantly lower than before RFA (0.80 ± 0.16)% (P = 0.002, Wilcoxon rank sum test). The success rate of thyroid remnant ablation was 91.7% (11/12), which was assessed 4–6 months after treatment. All patients reported neck discomfort and some are self-limiting, with no hoarseness, choking, or radiation thyroiditis symptoms. Five patients had puncture area pain, among which one patient had neck edema, which was relieved after prednisone treatment. Conclusion: Combined use of RAI therapy and radiofrequency ablation in treating excessive postsurgical thyroid remnant of DTC can be an effective approach and avoids re-operation. Long-term efficacy monitoring would further determine its feasibility.


How to cite this article:
Long B, Li L, Yao L, Chen S, Yi H, Ye X, Xu D, Wu P. Combined use of radioiodine therapy and radiofrequency ablation in treating postsurgical thyroid remnant of differentiated thyroid carcinoma.J Can Res Ther 2015;11:244-247


How to cite this URL:
Long B, Li L, Yao L, Chen S, Yi H, Ye X, Xu D, Wu P. Combined use of radioiodine therapy and radiofrequency ablation in treating postsurgical thyroid remnant of differentiated thyroid carcinoma. J Can Res Ther [serial online] 2015 [cited 2021 Apr 13 ];11:244-247
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2015;volume=11;issue=8;spage=244;epage=247;aulast=Long;type=0