Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 4  |  Page : 922--926

Prognostic significance and predictive performance of volume-based parameters of F-18 FDG PET/CT in squamous cell head and neck cancers


Sait Sager1, Sertaç Asa1, Mehmet Yilmaz2, Lebriz Uslu1, Betul Vatankulu1, Metin Halaç1, Kerim Sönmezoglu1, Bedii Kanmaz1 
1 Department of Nuclear Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
2 Department of Head and Neck Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

Correspondence Address:
Sait Sager
Department of Nuclear Medicine, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, Fatih, Istanbul
Turkey

Aim: It has been previously reported that metabolic tumor volume on positron emission tomography-computed tomography predicts disease recurrence and death in head-and-neck cancer. In this study, we assessed the prognostic value of metabolic tumor volume measured using F18-Fluorodeoxyglucose PET/CT in patients with head and neck squamous cell carcinoma. Materials and Methods: We analyzed the imaging findings of 74 patients (age 57 ± 16) retrospectively, with head and neck cancer who underwent PET/CT scan for staging and after treatment. Forty-tree patients had nasopharynx, 15 patients had hypopharynx, 9 patients had larynx, and 7 patients had oropharynx cancer. The MTVs of primary sites with or without lymph nodes were measured, and outcomes were assessed using the treatment response evaluation by the Response Evaluation Criteria in Solid Tumors and recurrence events during follow-up. Results: A total of 48 patients had complete response or no recurrence was detected as of in the last follow-up. Of the first PET/CT scan, the median primary tumor SUVmax was 18.8 and the median nodal SUVmax was 13.4. The median primary tumor MTV% 50s ranged from 11.12 cm 3 to 16.28 cm 3 , and the MTV after the therapy ranged from 1.18 cm 3 to 3.51 cm 3 . Conclusion: Metabolic tumor volume (MTV) represents tumor burden, which shows F18-Fluorodeoxyglucose uptake and has a potential value in predicting short-term outcome and disease-free survival in patients with head and neck cancer.


How to cite this article:
Sager S, Asa S, Yilmaz M, Uslu L, Vatankulu B, Halaç M, Sönmezoglu K, Kanmaz B. Prognostic significance and predictive performance of volume-based parameters of F-18 FDG PET/CT in squamous cell head and neck cancers.J Can Res Ther 2014;10:922-926


How to cite this URL:
Sager S, Asa S, Yilmaz M, Uslu L, Vatankulu B, Halaç M, Sönmezoglu K, Kanmaz B. Prognostic significance and predictive performance of volume-based parameters of F-18 FDG PET/CT in squamous cell head and neck cancers. J Can Res Ther [serial online] 2014 [cited 2020 Oct 20 ];10:922-926
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2014;volume=10;issue=4;spage=922;epage=926;aulast=Sager;type=0