Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 2  |  Page : 258--264

Prognostics of Cyclin-D1 expression with chemoradiation response in patients of locally advanced oral squamous cell carcinoma


Huma Khan1, Seema Gupta1, Nuzhat Husain2, Sanjeev Misra3, Navin Singh1, MPS Negi4 
1 Department of Radiotherapy, C.S.M. Medical University, Lucknow, Uttar Pradesh, India
2 Department of Pathology, C.S.M. Medical University, Lucknow, Uttar Pradesh, India
3 Department of Surgical Oncology, C.S.M. Medical University, Lucknow, Uttar Pradesh, India
4 Biometry and Statistics Division, Institute for Data Computing and Training, Lucknow, Uttar Pradesh, India

Correspondence Address:
Seema Gupta
Department of Radiotherapy, C.S.M. Medical University, Chowk City, Lucknow - 226 003, Uttar Pradesh
India

Objective: Cyclin-D1 has been strongly implicated in cell cycle proliferation particularly in the G1/S checkpoint in the cell cycle, and prognosis in many human malignancies. The present study evaluates its prognostic significance with chemoradiation response in patients of locally advanced oral squamous cell carcinoma (OSCC). Materials and Methods: A total of 97 OSCC patients (females = 19 and males = 78), aged 20-67 years and stage III/IV were recruited. Treatment response was assessed according to World Health Organization criteria. Cyclin-D1 expression in tumor tissue was estimated by immunohistochemical method and quantified as percentage positive nuclei. Results: The Cyclin-D1 expression showed significant (P < 0.01 or P < 0.001) association with tumor size, lymph node status, and clinical stage. After chemoradiation, there were 53.6% complete response (CR) and 34.0% partial response (PR) in primary tumor, and 49.5% CR and 39.2% PR in lymph node; giving an overall response rate of 85.6%. Further, the mean Cyclin-D1 expression showed significant (P < 0.05 or P < 0.001) and inverse association with chemoradiation responses (tumor size, lymph node status and overall treatment response). The 2-year progression-free and overall survival (OS) was 95.89% and 83.31% respectively. Multivariate Cox regression analysis found site of primary tumor, clinical stage, and Cyclin-D1 expression the significant (P < 0.05 or P < 0.01) and independent prognostic markers of OS and among these Cyclin-D1 expression showed the worst prognosis. The high Cyclin-D1 expression (>50%) also showed significantly lower survival in OSCC patients when compared with those had low (<10%) and moderate expressions (10-50%) (Logrank test: χ2 = 44.42, P < 0.001). Conclusion: The high Cyclin-D1 expression may serve as a poor prognostic marker in OSCC.


How to cite this article:
Khan H, Gupta S, Husain N, Misra S, Singh N, Negi M. Prognostics of Cyclin-D1 expression with chemoradiation response in patients of locally advanced oral squamous cell carcinoma.J Can Res Ther 2014;10:258-264


How to cite this URL:
Khan H, Gupta S, Husain N, Misra S, Singh N, Negi M. Prognostics of Cyclin-D1 expression with chemoradiation response in patients of locally advanced oral squamous cell carcinoma. J Can Res Ther [serial online] 2014 [cited 2020 Nov 26 ];10:258-264
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2014;volume=10;issue=2;spage=258;epage=264;aulast=Khan;type=0