Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 1  |  Page : 79--83

Surgery in cerebral metastases: Are numbers so important?


Alessandro Agnoletti1, Camilla Mencarani1, Pier Paolo Panciani2, Lucio Buffoni3, Gabriele Ronchetti5, Giannantonio Spena5, Fulvio Tartara1, Michela Buglione4, Manuela Pagano5, Alessandro Ducati1, Marco Fontanella2, Diego Garbossa1 
1 Department of Neuroscience, Division of Neurosurgery, University of Torino, Italy
2 Department of Neuroscience, Division of Neurosurgery, University of Torino; Division of Neurosurgery, University of Brescia, Italy
3 Department of Oncology, University of Torino, Italy
4 Department of Radiation Oncology, University of Brescia, Italy
5 Department of Oncology, Doctoral School in Biomedical Sciences and Oncology, University of Torino, Italy

Correspondence Address:
Pier Paolo Panciani
Department of Neuroscience, Division of Neurosurgery, University of Brescia, Italy. P.zza Spedali Civili, 1, 25123, Brescia
Italy

Background: The prognosis of cerebral metastases (MTS) is linked to progression of both systemic and local disease. The importance of MTS resection has been already pointed out. The observation of a high mortality for not-neurological causes confirms that the modern treatments allow a significant control of the disease within the nervous system. Nevertheless, management difficulties increase with multiple lesions and in these cases the role of surgery has still to be defined. Materials and Methods: We collected the clinical data of patients operated in two centers for cerebral MTS from lung carcinoma during 8 years. Patient selection for surgery followed definite criteria; the limit for multiple MTS was three. We analyzed the functional and survival outcomes of the cohort. Results and Conclusions: Our series included 242 patients: 105 had multiple MTS. Statistical analysis did not show significant differences in mean survival and outcomes between patients with single and multiple lesions. The decease occurred for neurological causes in 15.7% of cases. The selection of candidates for surgery requires several considerations and entails the success rate of this treatment. In patients with the multiple lesions who fulfilled the selection criteria we observed a nevertheless satisfying success after the operation. Our results imply that surgery may be applied also in selected patients with more diffuse intracranial disease. A pre-operative accurate patient selection is related to acceptable quality-of-life following the operation even in cases of multiple MTS.


How to cite this article:
Agnoletti A, Mencarani C, Panciani PP, Buffoni L, Ronchetti G, Spena G, Tartara F, Buglione M, Pagano M, Ducati A, Fontanella M, Garbossa D. Surgery in cerebral metastases: Are numbers so important?.J Can Res Ther 2014;10:79-83


How to cite this URL:
Agnoletti A, Mencarani C, Panciani PP, Buffoni L, Ronchetti G, Spena G, Tartara F, Buglione M, Pagano M, Ducati A, Fontanella M, Garbossa D. Surgery in cerebral metastases: Are numbers so important?. J Can Res Ther [serial online] 2014 [cited 2021 Sep 22 ];10:79-83
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2014;volume=10;issue=1;spage=79;epage=83;aulast=Agnoletti;type=0