Year : 2014 | Volume
: 10 | Issue : 1 | Page : 142--146
A novel role of the tumor size in pancreatic cancer as an ancillary factor for predicting resectability
Kun-Chun Chiang1, Chun-Hui Lee2, Chun-Nan Yeh3, Shir-Hwa Ueng4, Jun-Te Hsu3, Ta-Sen Yeh3, Yi-Yin Jan3, Tsann-Long Hwang3, Miin-Fu Chen3
1 Department of General Surgery, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei Shan Tao-Yuan, 333, Taiwan
2 Department of General Surgery, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, 204, Taiwan
3 Department of General Surgery, Chang Gung Memorial Hospital, 5, Fu-Hsing Street, Kwei-Shan, Taoyuan, Taiwan 333, R.O.C, Taiwan
4 Department of Pathology, Chang Gung Memorial Hospital, 5, Fu Hsing Street, Kwei Shan, Taoyuan, Taiwan 333, R.O.C, Taiwan
Background: Pancreatic adenocarcinoma (PCA) is a devastating disease. Only surgery can provide effective treatment. The resectability of pancreatic cancer is mainly determined by image studies. However, half of the patients deemed as operable, radiologically, are found to be inoperable during surgery. Previously, we have showed that both CA 19-9 and tumor size could predict PCA resectability, independently. Here, we aimed to determine the cut-off value for tumor size permitting PCA resectability by receiver operating characteristic (ROC) curve analysis.
Materials and Methods: We retrospectively reviewed 372 patients undergoing surgery for histopathologically proven PCA. We compared tumor sizes of patients in resectable and unresectable groups and analyzed them by the ROC curve.
Results: The tumor size in unresectable groups is significantly larger than that in the resectable group. The area under the ROC curve was 0.73 (95% confidence interval [CI], 0.665-0.789), which represented a good correlation between the tumor size and pancreatic cancer resectability. The PCA patients with a tumor diameter of > 4.8 cm had a 5.043-fold higher chance of unresectability than did those with a tumor diameter < 4.8 cm (odds ratio, 5.043; 95% CI, 3.221-7.894).
Conclusions: A tumor diameter > 4.8 cm is a potential ancillary parameter for determining the resectability of PCA in addition to traditional image studies. Diagnosis laparoscopy may be indicated for radiologically resectable PCA patients with tumor size > 4.8 cm to prevent unnecessary laparotomy.
Department of Surgery, Fu Hsing Street, Kwei-Shan, Taoyuan
|How to cite this article:|
Chiang KC, Lee CH, Yeh CN, Ueng SH, Hsu JT, Yeh TS, Jan YY, Hwang TL, Chen MF. A novel role of the tumor size in pancreatic cancer as an ancillary factor for predicting resectability.J Can Res Ther 2014;10:142-146
|How to cite this URL:|
Chiang KC, Lee CH, Yeh CN, Ueng SH, Hsu JT, Yeh TS, Jan YY, Hwang TL, Chen MF. A novel role of the tumor size in pancreatic cancer as an ancillary factor for predicting resectability. J Can Res Ther [serial online] 2014 [cited 2021 Sep 22 ];10:142-146
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2014;volume=10;issue=1;spage=142;epage=146;aulast=Chiang;type=0