Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 1  |  Page : 103--106

Immunohistochemical expression of syndecan-1 in oral dysplastic epithelium


B Lakkam1, B Majage2, M Astekar3, RS Gugwad2, G Giri4, S Ramasahayam5 
1 Department of Oral Pathology, Al-Ameen Dental College, Bijapur, India
2 Department of Prosthodontics, S. Nijalingappa Institute of Dental Sciences, Gulbarga, India
3 Department of Oral Pathology, Pacific Dental College, Udaipur, India
4 Department of Periodontics, S. Nijalingappa Institute of Dental Sciences, Gulbarga, India
5 Department of Oral Pathology, SVS Institute of Dental Sciences, Mahboobnagar, India

Correspondence Address:
B Lakkam
Department of Oral Pathology, Al Ameen Dental College, Bijapur
India

Background: In stratified squamous epithelia, syndecan-1 is proposed to function as a cellto cell adhesion molecule, and plays an important role in regulation of cell growth and differentiation during the developmental process. Oral cancer is a disease with complex etiology, so biological behavior in carcinomas preceded by dysplastic states is difficult to assess and predict its prognosis. Hence, syndecan-1, a recently recognized tumor marker has been proved to be an eminent diagnostic and prognostic tool in assessing biological behavior of various potentially premalignant andmalignant lesions. Materials and Methods: The study group consisted of 40 specimens of premalignant stateand 10 specimens of normal mucosa.Thesections were stained withhematoxylin and eosin, andimmunohistochemicallyusing syndecan-1 a primary antibody and was observed under light microscope. Results: Expression decreased with the decreasing grades of dysplasia. Conclusion: Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma.


How to cite this article:
Lakkam B, Majage B, Astekar M, Gugwad R S, Giri G, Ramasahayam S. Immunohistochemical expression of syndecan-1 in oral dysplastic epithelium.J Can Res Ther 2014;10:103-106


How to cite this URL:
Lakkam B, Majage B, Astekar M, Gugwad R S, Giri G, Ramasahayam S. Immunohistochemical expression of syndecan-1 in oral dysplastic epithelium. J Can Res Ther [serial online] 2014 [cited 2021 Sep 20 ];10:103-106
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2014;volume=10;issue=1;spage=103;epage=106;aulast=Lakkam;type=0