Year : 2013 | Volume
: 9 | Issue : 7 | Page : 178--182
Retrospective analysis of clinical and pathologic risk factors in liver resection for hepatic colorectal metastases
Lei Zhou1, Guochao Zhag1, Tao Tang1, Rui Lian2, Wenyue Wang1
1 Department of Gastrointestinal, China Japan Friendship Hospital, Beijing, China
2 Department of Emergency, China Japan Friendship Hospital, Beijing, China
Objective: To analyze the clinical and pathologic risk factors of surgical treatment for liver metastases from colorectal cancer.
Materials and Methods: The data on 98 patients who underwent liver resection for hepatic colorectal metastases were collected and analyzed retrospectively.
Results: Overall 1-, 3-, and 5-year survival rates after hepatectomy for metastases were 94.6%, 45.0%, and 22.3%, respectively. Gender, pathologic primary tumor stage, histologic differentiation, size of metastatic tumor, and type of metastases were not statistically significant prognostic factors (P > 0.05). The 5-year survival rate was significantly lower in patients with lymph node metastases from the primary site than that in patients without lymph node metastases (14.1% vs. 39.5%, P = 0.013); survival rate in patients with vascular invasion from the primary tumor was also significantly lower than in those without invasion (10.2% vs. 49.0%, P = 0.032). The survival rate in patients who had unilobar metastases was higher than that in patients who had bilobar metastases (25.3% vs. 0%, P = 0.012). The 5-year survival rates in solitary metastasis, two to three metastases, and with the transfer number ≥4 were 29.1%, 14.4%, and 0%, respectively (P = 0.019). Multivariate analysis revealed resection margin, distribution of metastases, and the number of metastases as the independent risk factors associated with the overall survival rates (P = 0.044, 0.037, and 0.005, respectively).
Conclusions: Surgical resection may be the only treatment modality for the cure of colorectal liver metastases. Negative resection margin, metastases confined to unilobar type, and number of metastases ≤3 are associated with better prognosis
Gastrointestinal Department, China Japan Friendship Hospital, Beijing
|How to cite this article:|
Zhou L, Zhag G, Tang T, Lian R, Wang W. Retrospective analysis of clinical and pathologic risk factors in liver resection for hepatic colorectal metastases.J Can Res Ther 2013;9:178-182
|How to cite this URL:|
Zhou L, Zhag G, Tang T, Lian R, Wang W. Retrospective analysis of clinical and pathologic risk factors in liver resection for hepatic colorectal metastases. J Can Res Ther [serial online] 2013 [cited 2021 Jun 17 ];9:178-182
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=7;spage=178;epage=182;aulast=Zhou;type=0