Year : 2013 | Volume
: 9 | Issue : 4 | Page : 672--679
Treatment and outcome in cancer cervix patients treated between 1979 and 1994: A single institutional experience
Shyamkishore Shrivastava1, Umesh Mahantshetty1, Reena Engineer1, Hemant Tongaonkar2, Jagadeesh Kulkarni3, Ketayun Dinshaw1
1 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
2 Gynae-Oncology Services, Tata Memorial Hospital, Mumbai, India
3 Department of Surgical Oncology, Bombay Hospital Institute of Medical Sciences, Mumbai, India
Introduction: A retrospective review in patients with carcinoma cervix to evaluate the changes and trends in demographics, evolution of protocols, and outcome analysis over 16 years.
Materials and Methods: This is a retrospective study of 6234 patients with carcinoma of the cervix treated with radical intent between 1979 and 1994. All the work-up, staging investigations, treatment details, radiation protocols, outcomes, and toxicities were noted, compiled, and analyzed.
Results: With a mean age of 46 years (range: 18-90 years; median: 45 years), 669 (11%) patients were in stage Ib, 284 (5%) were in stage IIa, 1891 (30%) were in stage IIb, 69 (1%) were in stage IIIa, and 3321 (53%) were in stage IIIb. With a median follow-up of 68 months (57-79 months) for the entire group, there was no significant difference in the outcome of 953 patients with international federation of gynecology and obstetrics (FIGO) Ib-IIa treated after radical surgery, pre-operative radiation therapy (pre-op RT) + Sx or after radical radiation; their disease-free survival (DFS) was 60-62% at 8 years. In our series of 1891 patients with stage IIb and 3321 with stage IIIb, a respective DFS of 56% and 40% was achieved at 8 years.
Conclusion: Over the last two decades, with the acquisition of newer facilities and inception of Joint Clinics, there has been a significant refinement in the treatment protocols and outcome. Improving radiation strategies to improve therapeutic ratio is the key to success.
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai - 12
|How to cite this article:|
Shrivastava S, Mahantshetty U, Engineer R, Tongaonkar H, Kulkarni J, Dinshaw K. Treatment and outcome in cancer cervix patients treated between 1979 and 1994: A single institutional experience.J Can Res Ther 2013;9:672-679
|How to cite this URL:|
Shrivastava S, Mahantshetty U, Engineer R, Tongaonkar H, Kulkarni J, Dinshaw K. Treatment and outcome in cancer cervix patients treated between 1979 and 1994: A single institutional experience. J Can Res Ther [serial online] 2013 [cited 2020 Oct 25 ];9:672-679
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=4;spage=672;epage=679;aulast=Shrivastava;type=0