Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 5  |  Issue : 2  |  Page : 102--106

Results of combined modality treatment for nasopharyngeal cancer


Ramachandran Venkitaraman1, S Ganapathy Ramanan2, A Vasanthan2, Tenali Gnana Sagar2 
1 Division of Clinical Oncology, Ipswich Hospital, United Kingdom
2 Division of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai - 400 036, India

Correspondence Address:
Ramachandran Venkitaraman
Consultant Clinical Oncologist, Ipswich Hospital NHS
United Kingdom

Context: Radiotherapy is the cornerstone of treatment in nasopharyngeal cancer (NPC); the addition of chemotherapy has shown improved results. Aims: To compare the results of concurrent chemoradiation with that of radiotherapy alone in NPC. Materials and Methods: One hundred and ninety consecutive NPC patients, without distant metastasis, who reported to the institute from January 1992 to December 2001, received external-beam radiation to 66 Gy in 33 fractions. Seventy-five of these patients received concurrent chemotherapy with cisplatin and 5-fluorouracil (5-FU) for four cycles. We compared the results of treatment in these two groups. Results: The 5-year disease-free survival rates were 40% and 60%, respectively, for patients who had radiotherapy alone and those who had chemoradiation (P = 0.002), while the median survival was 45 months and 60 months, respectively (P = 0.0028). Conclusion: A significant improvement in local control and survival was observed by the addition of concurrent chemotherapy with cisplatin and 5-FU to radical radiation in this nonrandomized study on patients with NPC.


How to cite this article:
Venkitaraman R, Ramanan S G, Vasanthan A, Sagar TG. Results of combined modality treatment for nasopharyngeal cancer.J Can Res Ther 2009;5:102-106


How to cite this URL:
Venkitaraman R, Ramanan S G, Vasanthan A, Sagar TG. Results of combined modality treatment for nasopharyngeal cancer. J Can Res Ther [serial online] 2009 [cited 2021 Jul 25 ];5:102-106
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=2;spage=102;epage=106;aulast=Venkitaraman;type=0