Journal of Cancer Research and Therapeutics

REVIEW ARTICLE
Year
: 2007  |  Volume : 3  |  Issue : 3  |  Page : 157--165

Brain metastases from breast cancer:Management approach


Tabassum Wadasadawala1, Sudeep Gupta2, Vaishali Bagul2, Namrata Patil1 
1 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
2 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Correspondence Address:
Sudeep Gupta
Department of Medical Oncology, Tata Memorial Hospital, Mumbai - 400 012
India

Brain metastases are a significant cause of morbidity and mortality in patients with breast cancer. HER-2 positivity is an increasingly recognized risk factor for the development of brain metastases. Although considerable progress has been made in the treatment of this complication, supportive measures like steroids, anti-seizure medication and whole-brain radiation remain the cornerstones of management in the majority of patients. The current review discusses the above and other issues like surgical excision, stereotactic radiotherapy, adjuvant radiation, radiosensitization and chemotherapy. A brief discussion of the recent evidence for the use of «SQ»HER-1/ HER-2«SQ»-targeted therapy is also present.


How to cite this article:
Wadasadawala T, Gupta S, Bagul V, Patil N. Brain metastases from breast cancer:Management approach.J Can Res Ther 2007;3:157-165


How to cite this URL:
Wadasadawala T, Gupta S, Bagul V, Patil N. Brain metastases from breast cancer:Management approach. J Can Res Ther [serial online] 2007 [cited 2021 Apr 14 ];3:157-165
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2007;volume=3;issue=3;spage=157;epage=165;aulast=Wadasadawala;type=0