Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2006  |  Volume : 2  |  Issue : 4  |  Page : 171--181

Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction


A Szasz, Gy. Vincze 
 Department of Biotechnics, St. Istvan University, Budapest, Hungary; OncoTherm, Budapest, Hungary

Correspondence Address:
A Szasz
Head of Biotechnics Department, St. Istvan University
Hungary

We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.


How to cite this article:
Szasz A, Vincze G. Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction.J Can Res Ther 2006;2:171-181


How to cite this URL:
Szasz A, Vincze G. Dose concept of oncological hyperthermia: Heat-equation considering the cell destruction. J Can Res Ther [serial online] 2006 [cited 2021 Apr 11 ];2:171-181
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2006;volume=2;issue=4;spage=171;epage=181;aulast=Szasz;type=0