Journal of Cancer Research and Therapeutics

ORIGINAL ARTICLE
Year
: 2005  |  Volume : 1  |  Issue : 1  |  Page : 38--40

A phase I trial of tocoferol monoglucoside in patients undergoing hemi-body radiation


NG Huilgol1, CK K Nair2, P Merhotra1, VT Kagiya3 
1 Division of Radiation Oncology, Nanavati Hospital, Vile Parle (W), Mumbai, India
2 Radiation Biochemistry Section, Radiation Biology and Health Science Division, BARC, Anushaktinagar, Mumbai, India
3 Kinki Invention Center, Yoshida Kawahara.cho 14, Sakyo-ku, Kyoyo - 606 8305, Japan

Correspondence Address:
N G Huilgol
Division of Radiation Oncology, Nanavati Hospital, Vile Parle (W), Mumbai
India

Purpose: To evaluate Tocoferol monoglucoside (TMG), a water soluble vit. E. in a phase I trial, as a radiation protector in those undergoing hemi-body radiation for disseminated disease. Materials and Methods: Patients scheduled to receive modified hemi-body radiation were accrued for the study. Patients not only had disseminated skeletal disease but, were heavily pretreated Seven patients were accrued for the study. Patients received 1 and 2 gms of TMG. 30-40 minutes before hemibody radiation. A dose of 600 cGy was delivered on telecobalt equipment at mid plane. Immediate Toxicities were evaluated as well as response to pain. Results: All the seven patients underwent radiation uneventfully. There was no drug related toxicity. Pain relief was adequate. Conclusion: Tocoferol monoglucoside an effective antioxidant with no significant acute toxicity, when administered in a dose of 1 or 2 gms per oral route. TMG being water-soluble can have global antioxidant and radio protective effects. This needs further clinical evaluation.


How to cite this article:
Huilgol N G, Nair CK, Merhotra P, Kagiya V T. A phase I trial of tocoferol monoglucoside in patients undergoing hemi-body radiation .J Can Res Ther 2005;1:38-40


How to cite this URL:
Huilgol N G, Nair CK, Merhotra P, Kagiya V T. A phase I trial of tocoferol monoglucoside in patients undergoing hemi-body radiation . J Can Res Ther [serial online] 2005 [cited 2021 Sep 27 ];1:38-40
Available from: https://www.cancerjournal.net/article.asp?issn=0973-1482;year=2005;volume=1;issue=1;spage=38;epage=40;aulast=Huilgol;type=0