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Role of immunohistochemistry markers in neoplastic lung lesions


 Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of The West Indies, Trinidad and Tobago

Correspondence Address:
Srikanth Umakanthan,
Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of The West Indies, Mount Hope Campus
Trinidad and Tobago
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_187_19

Objectives: The objective of the evaluate was to study and determine the usefulness of immunohistochemistry (IHC) staining in neoplastic lung lesions. Materials and Methods: We evaluated seven IHC stains in fifty lung cancers that included adenocarcinoma (AC), squamous cell carcinoma (SCC), small cell carcinoma, and carcinoid tumors. Results: P63 was expressed in all the cases of SCCs and thyroid transcription factor-1 (TTF-1) was expressed in all cases of ACs. CK 5/6 was expressed in 77.77% of SCCs and CK 7 was expressed in 92.59% of ACs. Synaptophysin and chromogranin-A were expressed in 100% of neuroendocrine (NE) carcinomas. Conclusion: P63 and TTF-1 are sensitive markers for SCCs and ACs. Synaptophysin and Chromogranin-A are sensitive markers for NE carcinomas.


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    -  Umakanthan S
    -  Chalapathi Rao A V
    -  Mohammed W
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