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Rucabarib: A new lease of life for ovarian cancer patients


1 Department of Community Medicine, SN Medical College, Agra, UP and Advisory Epidemiologist, Global Data Communications, London, United Kingdom
2 Department of Obstetrics and Gynaecology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Correspondence Address:
Sandeep Sachdeva,
43, Ravenswood Avenue, Ipswich, Suffolk IP3 9GG
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_458_19

Background: Rucaparib is a drug with potential as maintenence monotherapy in ovarian cancers irrespective of genetic mutation. Methods: The results of the ARIEL 3 trial were analysed for the drug's prospects towards cure in ovarian and other pelvic malignancies. Results: Ovarian cancer patients with highly malignant tumors and relapses on platinum based chemotherapy exhibited statistically significant reductions in tumor size with maintenance Rucaparib therapy vis a vis placebo. Conclusion: Genetic heterogeneity of the tumor did not have an impact upon Rucaparib efficacy in ovarian carcinoma. More malignant and relapsed variants can effectively be treated with Rucaparib, thereby improving survival rates and quality of life.


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