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Acinic cell carcinoma of the parotid gland with neuroendocrine differentiation
Ashutosh Rath1, Reena Tomar1, Radhika Agarwal1, Meeta Singh1, Shyama Jain1, Nita Khurana1, Praveen Kumar Rathore2
1 Department of Pathology, Maulana Azad Medical College, New Delhi, India
2 Department of Otorhinolaryngology And Head And Neck Surgery, Maulana Azad Medical College, New Delhi, India
Correspondence Address:
Reena Tomar,
Department of Pathology, Maulana Azad Medical College, New Delhi
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jcrt.JCRT_645_19
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Acinic cell carcinoma (ACC) is a malignant salivary gland tumor characterized by tumor cells displaying acinar features. Usually presenting as a slow-growing tumor, ACC, however, may show dedifferentiation to a higher grade including neuroendocrine carcinoma. In addition, ACC may rarely show focal neuroendocrine differentiation without any frank evidence of neuroendocrine carcinoma. We describe such a case of ACC of the parotid gland in a 65-year-old female, which showed neuroendocrine differentiation. The diagnostic clues, immunohistochemistry panel, and prognostic and treatment aspects are also presented.
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