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Combined effect of oral famotidine and cimetidine on the survival of lethally irradiated mice: An in vivo study
Karim Afsar dizaj1, Ali Shabestani Monfared2, Hossein Mozdarani3, Ali Naeiji4, Abolfazl Razzaghdoust5, Karimollah Hajian-tilaki6, Bahareh Aboufazeli1, Fatemeh Niksirat7, Sajad Borzoueisileh8
1 Student Research Committee, Babol University of Medical Sciences, Babol, Iran
2 Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3 Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4 Radiology Technology Department, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Urology and Nephrology Research Center, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Statistic and Epidmiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
7 Cancer Research Center; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
8 Student Research Committee; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Correspondence Address:
Ali Shabestani Monfared,
Babol University of Medical Sciences, Ganjafrooz Street, Babol
Iran
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jcrt.JCRT_349_19
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Aims: The study aims at evaluating the effects of the combinatory famotidine/cimetidine diet on radiated mice's survival.
Materials and Methods: Two hundred and seventy male mice were categorized into 11 groups, a number of which were comprised of subgroups too. The groups under analysis were posed to varying doses of gamma-radiation, including 6, 7, 8, and 9 Gy, followed by treatments using various drug doses 2, 4, and 8 mg/kg, with survival fractions as long as a month after irradiation being measured and recorded.
Results: LD50/30 was calculated as 7.47 Gy for the group with radiation only. Following mouse treatment with a concentration of 4 and 20 mg/kg for famotidine and cimetidine, respectively, the survival fraction for the mice grew significantly compared to LD50/30. The combinatory famotidine/cimetidine diet had a higher dose-reduction factor (DRF) than single doses of the drug in radioprotection. The DRF for combinatory famotidine/cimetidine, famotidine, and cimetidine diets was 08.09, 1.1, and 1.01, respectively.
Conclusions: Results imply that the combined regimen of famotidine + cimetidine in radioprotection had no significant higher DRF than with regimens including each of them separately. In addition, we did not find a synergic effect of combined oral famotidine and cimetidine on irradiated mice.
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