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Influence of hormone receptors in breast cancer survival with correlation to place of residence
Jagannath Dev Sharma1, Amal Chandra Kataki2, Manoj Kalita3
1 Department of Pathology, Dr. B Borooah Cancer Institute, Guwahati, Assam, India
2 Dr. B Borooah Cancer Institute, Guwahati, Assam, India
3 Population Based Cancer Registry Guwahati, Dr. B Borooah Cancer Institute, Guwahati, Assam, India
Correspondence Address:
Manoj Kalita,
Population Based Cancer Registry, Dr. B Borooah Cancer Institute, Gopinath Nagar, Guwahati - 781 016, Assam
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jcrt.JCRT_402_19
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Introduction: Breast cancer is commonly diagnosed cancer in women. Tumor receptors estrogen receptor (ER) and progesterone receptor (PR) are well recognized prognostic factors for breast cancer.
Materials and Method: Data from the department of pathology for the 5-year period (2010 to 2014) is used for analysis for Kamrup district of Assam, India. Kaplan Meir method was used to evaluate survival rate.
Result: The overall 5-year survival is observed as 54.6%. There is a 10.6% improvement in survival was recorded among those who living in the urban areas. The risk of death was 40% higher for those who were resides in rural areas compared to urban areas (P = 0.070). There is a 6 fold variation in survival was observed according to their stage at presentation. Hormone receptors found to be play an important role in survival outcome. Patients with ER/PR+ (positive) status have 13.6% higher survival rate than those with ER/PR-. The overall survival for ER/PR positive is 72.1% compared to 58.5% of ER/PR negative.
Conclusion: From the study it is observed that population with positive hormone receptors (ER/PR +) and living in the urban areas is experiencing survival rate.
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