Hepatitis B in hepatocellular carcinoma patients and its correlation with alpha-fetoprotein and liver enzymes
Richa Surit1, Ravi Shekhar1, Dinesh Kumar Sinha2, Sanjeet Kumar Singh3, Uday Kumar1, Nidhi Prasad4
1 Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
2 Department of Radiation Oncology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
3 Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
4 Department of Microbiology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
Dinesh Kumar Sinha,
Department of Radiation Oncology, Regional Cancer Centre, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna - 800 014, Bihar
Source of Support: None, Conflict of Interest: None
Background: Hepatocellular carcinoma (HCC) in India ranges from 0.7 to 7.5 for men and 0.2 to 2.2 for women, per 100,000 population per year. The major risk factors for the development of HCC are infection with hepatitis B virus (HBV), hepatitis C virus, and cirrhosis of liver. Alpha-fetoprotein (AFP) and liver enzymes are widely used by clinicians for diagnostic purpose in HCC.
Aims and Objective: This study was conducted in HCC patients related to HBV infection and to assess the significance of AFP and liver enzymes in it.
Materials and Methods: Blood samples of 68 patients were taken. The samples were analyzed for AFP and liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]). Liver enzymes were estimated by auto analyzer OLYMPUS AU400. AFP was analyzed by chemiluminescence immunoassay.
Results: The mean values of AFP in serum hepatitis B surface antigen (HBsAg) negative and positive patients ranges from 22745.4 to 23269.3 ng/ml with P = 0.921. The mean value of ALP in HbsAg-negative patients was 418 U/ml, whereas in positive patients, it was 310 U/ml. Both the groups did not show any significant changes in AFP levels. The ALP showed slight rise in negative group. The other parameters did not show significant rise in all patients.
Conclusion: These values suggest that there was no significant influence of viral etiology on AFP and liver enzymes level in HCC patients.