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Hepatic necrosis following yttrium-90 radioembolization for hepatocellular carcinoma in a patient with a recent history of external radiotherapy

1 Department of Interventional Radiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China
2 Department of Radiology, Mayo Clinic, Jacksonville, FL, USA

Correspondence Address:
Weiping Wang,
Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_27_19

Hepatobiliary complications from yttrium-90 (90Y) radioembolization have been described previously but are often clinically inconsequential. This report describes the case of a patient in whom a large area of hepatic necrosis occurred after the patient underwent both stereotactic body radiotherapy and glass-based90Y radioembolization for the management of hepatocellular carcinoma. This case suggests that90Y microspheres can cause severe local hepatic injury when administered after external radiotherapy.

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