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Identification of activated pathways in lung adenocarcinoma based on network strategy
Bo Yu1, Tao Li2, Juan Chen1, Feng-Qiang Wang1, Jian-Hua Fu2, Shu-Mei Liu1, Yan Wang1, Xin Zhang1, Hai-Tao Yang1
1 Department of Respiratory Medicine, People's Hospital of Liaocheng, Liaocheng 252000, China
2 Department of Thoracic Surgery, People's Hospital of Liaocheng, Liaocheng 252000, China
Correspondence Address:
Juan Chen,
Department of Respiratory Medicine, People's Hospital of Liaocheng, No. 67, East Dongchang Road, Liaocheng 252000, Shandong Province
China
 Source of Support: None, Conflict of Interest: None
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Background: Lung adenocarcinoma has increased incidence over the past years and is the cause for almost 50% of deaths attributable to lung cancer. The objective of this paper is to identify activated pathways associated with lung adenocarcinoma based on gene co-expression network analysis.
Materials and Methods: Kyoto Encyclopedia of Genes and Genomes pathway analysis of dysregulated genes was performed based on Expression Analysis Systematic Explorer test to illuminate the biological pathways. Co-expression networks of lung adenocarcinoma in different tumor Stages (IA, IB, IIA, IIB, IIIA, IIIB, and IV) were constructed by Empirical Bayes approach to reweight gene pair scores. Pathway activity analysis was conducted to compute the distribution of pathways in different stages and to identify “activated” pathways in lung adenocarcinoma.
Results: We evaluated 211 dysregulated genes between lung adenocarcinoma patients and normal controls. Pathway activity analysis was performed and P values of pathways, which obtained from co-expression networks (Stage IA, IB, IIA, IIB, IIIA, IIIB, and IV), were calculated. Cell cycle, progesterone-mediated oocyte maturation, and oocyte meiosis were activated during all stages in lung adenocarcinoma.
Conclusion: We successfully identified three activated pathways (cell cycle, progesterone-mediated oocyte maturation, and oocyte meiosis) in different Stages (IA, IB, IIA, IIB, IIIA, IIIB, and IV) of lung adenocarcinoma. |
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