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LETTER TO THE EDITOR
Year : 2021  |  Volume : 17  |  Issue : 4  |  Page : 1134-1135

Association of hypoxia-inducible factor-1α polymorphisms with susceptibility to nonsmall-cell lung cancer: A summative analysis


1 TWS Medical Center, Bangkok, Thailand
2 Department of Biological Science, Joseph Ayo Babalola University, Ikeji, Arakeji, Nigeria

Date of Submission15-Aug-2019
Date of Decision09-Oct-2019
Date of Acceptance30-Dec-2019
Date of Web Publication10-May-2021

Correspondence Address:
Pathum Sookaromdee
TWS Medical Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_607_19

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How to cite this article:
Sookaromdee P, Wiwanitkti V. Association of hypoxia-inducible factor-1α polymorphisms with susceptibility to nonsmall-cell lung cancer: A summative analysis. J Can Res Ther 2021;17:1134-5

How to cite this URL:
Sookaromdee P, Wiwanitkti V. Association of hypoxia-inducible factor-1α polymorphisms with susceptibility to nonsmall-cell lung cancer: A summative analysis. J Can Res Ther [serial online] 2021 [cited 2021 Dec 4];17:1134-5. Available from: https://www.cancerjournal.net/text.asp?2021/17/4/1134/315671



Sir,

The genetic underlying factors affecting the susceptibility of lung cancer is an interesting issue in chest medicine. There are many genetic variants that are mentioned for interrelationship with lung cancer. Of several genetic polymorphisms, the hypoxia-inducible factor-1α (HIF1A) polymorphism is widely studied. In fact, the effect of this genetic polymorphism is mentioned in several cancers including lung cancer.[1],[2],[3],[4],[5] Regarding the HIF1A polymorphism, the HIF1A Pro582Ser, and HIF1A Ala588Thr are the two variants that are widely studied for interrelationship with lung diseases. Here, the authors perform a summative analysis on the studies regarding the genetic epidemiology of HIF1A Pro582Ser and HIF1A Ala588Thr among patients with susceptibility to non-small-cell lung cancer.

First, the authors search for the available published data in the international database PubMed to recruit the studies on HIF1A Pro582Ser and HIF1A Ala588Thr among patients with susceptibility to nonsmall-cell lung cancer. The reports with complete data and published in English are included for further summative analysis. From the literature search, the data form two included publications[1],[2] are retrospectively summarized and analyzed. Regarding HIF1A Pro582Ser, there are 438 cases and 300 controls. Regarding HIF1A Ala588Thr, there are 437 cases and 300 controls. From the summative retrospective analysis, the gene frequency distribution is presented in [Table 1]. From the Chi-square test, there is a significant association between genotype and lung cancer in the HIF1A Pro582Ser study (P = 0.02) and there is also a significant association between genotype and lung cancer in HIF1A Ala588Thr study (P = 0.01). Based on the present study, it can confirm the association between HIF1A polymorphisms and susceptibility to nonsmall-cell lung cancer.
Table 1: Gene frequency distribution on hypoxia-inducible factor-1α Pro582Ser and hypoxia-inducible factor-1α Ala588Thr studies

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Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
 > References Top

1.
Kim SJ, Hwang SH, Kim IJ, Lee MK, Lee CH, Lee SY, et al. The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients. J Exp Clin Cancer Res 2010;29:69.  Back to cited text no. 1
    
2.
Kuo WH, Shih CM, Lin CW, Cheng WE, Chen SC, Chen W, et al. Association of hypoxia inducible factor-1α polymorphisms with susceptibility to non-small-cell lung cancer. Transl Res 2012;159:42-50.  Back to cited text no. 2
    
3.
Sun X, Liu YD, Gao W, Shen SH, Li M. HIF-1α -1790GA polymorphism significantly increases the risk of digestive tract cancer: A meta-analysis. World J Gastroenterol 2015;21:1641-9.  Back to cited text no. 3
    
4.
Wang T. Association between HIF1α 1772 C/T polymorphism and breast cancer susceptibility: A systematic review. Crit Rev Eukaryot Gene Expr 2017;27:297-304.  Back to cited text no. 4
    
5.
Ye Y, Wang M, Hu S, Shi Y, Zhang X, Zhou Y, et al. Hypoxia-inducible factor-1α C1772T polymorphism and cancer risk: A meta-analysis including 18,334 subjects. Cancer Invest 2014;32:126-35.  Back to cited text no. 5
    



 
 
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