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ORIGINAL ARTICLE
Year : 2021  |  Volume : 17  |  Issue : 1  |  Page : 46-50

Evaluation of newly identified Ikaros family zinc finger 1 loci in colorectal cancer


1 School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India
2 Department of Biotechnology, Kashmir University, Srinagar, Jammu and Kashmir, India
3 Indian Council of Medical Research-Centre for Advance Research, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India
4 Department of Medicine, ASCOMS, Jammu, Jammu and Kashmir, India
5 Department of Radiotherapy, Government Medical College, Jammu, Jammu and Kashmir, India
6 Centre for Molecular Biology, Central University of Jammu, Jammu, Jammu and Kashmir, India
7 Department of Botany, Central University of Jammu, Jammu, Jammu and Kashmir, India

Correspondence Address:
Rakesh Kumar
Assistant Professor, School of Biotechnology Shri Mata Vaishno Devi University Katra., Jammu and Kashmir
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_844_20

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Aim: In this study, we evaluated the association of rs6964823 of the Ikaros Family Zinc Finger 1 (IKZF1) gene with the risk of colorectal cancer (CRC) within the population of Jammu and Kashmir (J and K). Materials and Methods: The variant rs6964823 of the IKZF1 gene was genotyped using the TaqMan allele discrimination assay for 578 individuals (182 CRC cases and 396 healthy controls). The association of single-nucleotide polymorphisms with the disease was evaluated using logistic regression. Results: It was observed that the variant rs6964823 (IKZF1) showed a significant association with an adjusted allelic odds ratio (OR) of 1.74 (1.34–2.27) at 95% confidence interval (CI), P ≤ 0.05. The dominant model (AA + AG vs. GG) was also applied, where the adjusted OR was 3.096 (2.011–4.76) at 95% CI, P > 0.05. Conclusions: It was found that the variant rs6964823 of the IKZF1 gene is associated with a higher risk of CRC within the population of J and K.


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