|LETTER TO THE EDITOR
|Year : 2021 | Volume
| Issue : 1 | Page : 291
Characteristics of BRAF V600K versus V600E: Effect of molecular weight change in melanoma
Beuy Joob1, Viroj Wiwanitkit2
1 Sanitation 1, Medical Academic Center, Bangkok, Thailand
2 Department of Tropical Medicine, Hainan Medical University, Haikou, China
|Date of Submission||03-Jul-2018|
|Date of Decision||02-Sep-2018|
|Date of Acceptance||06-Dec-2018|
|Date of Web Publication||20-Aug-2019|
Sanitation 1, Medical Academic Center, Bangkok
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Joob B, Wiwanitkit V. Characteristics of BRAF V600K versus V600E: Effect of molecular weight change in melanoma. J Can Res Ther 2021;17:291
Melanoma is important cancer. The genetic underlying factor for the susceptibility/resistance of the cancer to treatment is very interesting. The effect of the genetic polymorphism should be discussed. Li et al. recently found that “elements of energy metabolism and protein translation pathways were upregulated” in V600K tumors compared with V600E tumors. We would like to share ideas on this finding. In fact, the energy requirement in metabolism can be altered as a result of the mutation, and this might affect the susceptibility/resistance of the tumor to treatment as well as the severity/prognosis of the disease. Focusing on V600K and V600E mutations, the calculation for molecular weight change based on basic quantum calculation as presented in previous reports on important medical disorders,, can show that the changes in V600K and V600E equal to 29 and 30/mol, respectively. This means the required energy per molecule to finalize the protein-translation pathway or the case of V600K should be slightly less than that of V600E. Hence, this finding is concordant and supports the observations in the study by Li et al. Indeed, in a recent report by Hallmeyer et al., the response rate to treatment in V600K mutation is slightly higher than other mutation including to V600E. In fact, calculating the stability of BRAF dimers, either with itself or other RAF proteins which can make some senses. Still, it is clear how such stability calculations would translate into the differences in biology or clinical observations between V600K and V600E mutants. Here, it is clearly noted that “molecular weight change” contribute to the observe difference in susceptibility/resistance.
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Conflicts of interest
There are no conflicts of interest.
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