LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir

Ruchi Shah; Varun Sharma; Hemender Singh; Indu Sharma; Gulzar Ahmed Bhat; Idrees Ayoub Shah; Beenish Iqbal; Rumisa Rafiq; Najma Nissa; Mansha Muzaffar; Malik Tariq Rasool; Ghulam Nabi Lone; Sandeep Kaul; Mohd Maqbool Lone; Ekta Rai; Nazir Ahmed Dar; Swarkar Sharma

doi:10.4103/jcrt.JCRT_613_19

ORIGINAL ARTICLE

Year : 2020 | Volume : 16 | Issue : 8 | Page : 156-159

LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir

Ruchi Shah¹, Varun Sharma¹, Hemender Singh¹, Indu Sharma¹, Gulzar Ahmed Bhat², Idrees Ayoub Shah², Beenish Iqbal², Rumisa Rafiq², Najma Nissa², Mansha Muzaffar², Malik Tariq Rasool³, Ghulam Nabi Lone⁴, Sandeep Kaul⁵, Mohd Maqbool Lone³, Ekta Rai¹, Nazir Ahmed Dar², Swarkar Sharma¹
¹ Human Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India
² Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India
³ Department of Radiation Oncology, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
⁴ Department of CVTS, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
⁵ Department of Surgical Oncology, SMVDNH Superspeciality Hospital, Katra, Jammu and Kashmir, India

Correspondence Address:
Nazir Ahmed Dar
Department of Biochemistry, University of Kashmir, Srinagar - 180 001, Jammu and Kashmir
India
Swarkar Sharma
Human Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra - 182 320, Jammu and Kashmir
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jcrt.JCRT_613_19

Background: Leucine-rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome-wide association study in an Asian population. However, this association has not been replicated in any Indian population despite high incidence of the disease. Materials and Methods: In the present case–control study, 166 cases and 459 controls were included. Taqman assay technique using real-time PCR was employed to investigate the association of the variant with esophageal cancer in the population of Jammu and Kashmir (J&K). The Hardy-Weinberg equilibrium for rs2494938 was assessed using the Chi-square test. The allele- and genotype-specific risk was estimated by odds ratio (OR) with 95% confidence interval (CI). Results: Variant rs2494938 was observed to be significantly associated with esophageal cancer with an allelic OR of 1.59 (1.23–2.04 at 95% CI, P = 0.0003). Conclusion: The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India.

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