Immune abscopal effect of microwave ablation for lung metastases of endometrial carcinoma

Hui Xu; Wenqiao Sun; Yongmei Kong; Yahan Huang; Zhigang Wei; Licheng Zhang; Jing Liang; Xin Ye

doi:10.4103/jcrt.JCRT_1399_20

CASE REPORT

Year : 2020 | Volume : 16 | Issue : 7 | Page : 1718-1721

Immune abscopal effect of microwave ablation for lung metastases of endometrial carcinoma

Hui Xu¹, Wenqiao Sun², Yongmei Kong¹, Yahan Huang¹, Zhigang Wei¹, Licheng Zhang², Jing Liang¹, Xin Ye¹
¹ Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Weihai, Shandong, China
² Department of Minimally Invasive Interventional Oncology, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, Shandong, China

Correspondence Address:
Jing Liang
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jingshi Road, Jinan, Shandong Province, 250014
China
Licheng Zhang
Department of Minimally Invasive Interventional Oncology, Weihai Municipal Hospital Affiliated to Shandong University, Heping Road, Huancui District, Weihai City, 264200
China
Xin Ye
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jingshi Road, Jinan, Shandong Province, 250014
China

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jcrt.JCRT_1399_20

Increasing evidence support that microwave ablation (MWA) induces spontaneous abscopal regression of the tumor, also called as the abscopal effect. Although the abscopal effect after MWA is a rare event, several studies have suggested that this effect is the result of the activation of the immune system induced by the death of immunogenic tumor cells. Here, we have presented the case of a 65-year-old woman with primary endometrial cancer who developed bilateral pulmonary metastases. After local MWA of one lesion in her right lung, progressive regression of the other lesions in the right and left lungs was recorded. This case supports the hypothesis that the abscopal effect is attributable to the activation of the systemic immune response.

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