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CASE REPORT
Year : 2020  |  Volume : 16  |  Issue : 7  |  Page : 1710-1713

Spontaneous regression of recurrent hepatocellular carcinoma with multiple lung metastases


1 Department of Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
2 State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu, China

Correspondence Address:
Wei-Li Wang
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215 123
China
Zhi Li
Department of Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_766_20

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Spontaneous regression (SR) of hepatocellular carcinoma (HCC) is a rare phenomenon but its true incidence is much higher than expected. We report a recurrent HCC who experienced SR both in intrahepatic lesion and lung metastasis. Serum alpha-fetoprotein decreased dramatically from more than 1000 μg/L to normal range. In addition, we reviewed 11 similar case reports published in recent 5 years. We find that the interval from diagnosis to the recognition of SR is very short (4 m, 1–14 m). Therefore, we speculate the mechanism of SR should be a severe systemic reaction, and immune activation is the most likely conjecture.


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