Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 16  |  Issue : 7  |  Page : 1582-1587

Efficacy and safety of drug-eluting bead-transcatheter arterial chemoembolization using 100–300 μm versus 300–500 μm CalliSpheres microspheres in patients with advanced-stage hepatocellular carcinoma


1 Department of Interventional Therapy, The Affiliated Hospital of Qingdao University, Qingdao, China
2 Department of Interventional Therapy, Rizhao Central Hospital, Qingdao, China
3 Department of Radiology, Qingdao Women and Children's Hospital, Qingdao, China
4 Department of Abdominal Ultrasound, The affiliated Hospital of Qingdao University, Qingdao, China
5 Qingdao Center for Disease Control and Pervention, Qingdao, China

Correspondence Address:
Yanhua Wang
Department of Interventional Medical Therapy, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_543_20

Rights and Permissions

Purpose: To evaluate the efficacy and safety of drug-eluting bead-transcatheter arterial chemoembolization (DEB-TACE) using 100–300 μm versus 300–500 μm CalliSpheres microspheres (CSMs) for treating multiple hepatocellular carcinoma (HCC) with the largest nodule measuring between 5 and 10 cm. Methods: Eighty-one advanced-stage HCC patients treated by DEB-TACE between January 2017 and March 2020 were retrospectively analyzed. There were 48 patients in the 100–300 μm group and 33 patients in the 300–500 μm group. Treatment response, liver function tests, and complications were compared between the two groups. Results: At 6 months, the response rates in the 100–300 μm group were higher than those in the 300–500 μm group (P < 0.05). Disease control rates in the 100–300 μm group were higher than those in the 300–500 μm group at 1, 3, and 6 months (P < 0.05). Progression-free survival (PFS) and overall survival (OS) were longer in the 100–300 μm group (P < 0.05). Visual analog score points were higher in the 300–500 μm group (P < 0.05). There were no significant differences in complications between the two groups. Conclusion: The use of small-diameter CSMs in multiple HCC with the largest nodule size of 5–10 cm provides better treatment response and longer PFS and OS for treating advanced-stage HCC.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed194    
    Printed0    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal