|Year : 2020 | Volume
| Issue : 5 | Page : 1093-1099
Magnetic resonance-guided ablation of liver tumors: A systematic review and pooled analysis
Jianfeng Xiang1, Ming Liu2, Rongbin Lu3, Ligang Wang4, Yujun Xu2, Xiangmeng He2, Roberto Blanco5, Chengli Li2
1 Department of Interventional MRI, Shandong Medical Imaging Research Institute Affiliated to Shandong University, Jinan, Shandong; Department of Intervention, Shanghai Fengxian District Central Hospital, Shanghai, China
2 Department of Interventional MRI, Shandong Key Laboratory of Advanced Medical Imaging Technologies and Applications, Shandong Medical Imaging Research Institute Affiliated to Shandong University, Jinan, Shandong, China
3 Department of Nuclear Medicine, Tai'an Central Hospital, Tai'an, Shandong, China
4 Department of Interventional Therapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China
5 The Southwestern Finland Imaging Centre, Turku University Hospital, Turku, Finland
|Date of Submission||13-Dec-2019|
|Date of Decision||20-Mar-2020|
|Date of Acceptance||10-Apr-2020|
|Date of Web Publication||29-Sep-2020|
Department of Interventional MRI, Shandong Key Laboratory of Advanced Medical Imaging Technologies and Applications, Shandong Medical Imaging Research Institute Affiliated with Shandong University, Jinan, Shandong
The Southwestern Finland Imaging Centre, Turku University Hospital, Turku
Source of Support: None, Conflict of Interest: None
Purpose: The purpose of this study is to study the clinical outcomes of different types of magnetic resonance (MR)-guided ablation for the treatment of liver tumors by performing a systematic review and pooled analysis.
Materials and Methods: A comprehensive literature search was performed for clinical trials published from January 1997 to October 2019 in PubMed, the Web of Science, Embase, and the Cochrane Library. Pooled analyses were performed to obtain the complete ablation (CA), complication, progression-free survival (PFS), and overall survival (OS) rates.
Results: Thirty studies were eligible, including four studies on MR-guided microwave ablation (MWA); 14 studies on MR-guided radiofrequency ablation (RFA); one study on both MR-guided MWA and RFA; eight studies on MR-guided, laser-induced thermotherapy (LITT); two studies on MR-guided percutaneous cryoablation (PC); and one study on MR-guided percutaneous ethanol injection (PEI). The CA rates in patients who underwent RFA, MWA, LITT, PC, and PEI were 95.60%, 98.86%, 77.78%, 47.92%, and 85.71%, respectively. The most frequent complications were pain (27.66%, 13/47) and postablation syndrome (27.66%, 13/47) in the PC group; pleural effusion (8.11%, 119/1,468) and subcapsular hematoma (2.25%, 33/1,468) in the LITT group; pleural effusion (2.67%, 2/75) in the MWA group; and subcapsular hematoma (4.18%, 20/478) and post-ablation syndrome (2.93%, 14/478) in the RFA group. There were few studies reporting PFS and OS.
Conclusions: MR-guided ablation is a practicable alternative treatment for liver tumors, especially MR-guided RFA and MWA, which have high rates of CA and low occurrences of complications.
Keywords: Ablation, liver tumors, magnetic resonance guidance, pooled analysis, systematic review
|How to cite this article:|
Xiang J, Liu M, Lu R, Wang L, Xu Y, He X, Blanco R, Li C. Magnetic resonance-guided ablation of liver tumors: A systematic review and pooled analysis. J Can Res Ther 2020;16:1093-9
|How to cite this URL:|
Xiang J, Liu M, Lu R, Wang L, Xu Y, He X, Blanco R, Li C. Magnetic resonance-guided ablation of liver tumors: A systematic review and pooled analysis. J Can Res Ther [serial online] 2020 [cited 2021 Apr 13];16:1093-9. Available from: https://www.cancerjournal.net/text.asp?2020/16/5/1093/296425
| > Introduction|| |
Currently, hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and is the third leading cause of cancer-related deaths. The incidence and mortality rates of HCC are projected to further increase in coming decades. In addition, approximately 40%–70% of patients with colorectal cancer and 4%–14% of patients with gastric cancer develop hepatic metastases during the course of their diseases, and their prognosis is relatively poor., However, only a minority of patients with either primary or secondary liver tumors are the candidates for resection because they have impaired liver function or concurrent disease. Image-guided ablation methods, including percutaneous ethanol injection (PEI), laser-induced thermotherapy (LITT), radiofrequency ablation (RFA), and microwave ablation (MWA), have been used in the treatment of nonsurgical patients with primary or metastatic liver tumors.,,,,
Magnetic resonance imaging (MRI) is widely accepted in interventional therapy due to its sensitivity to temperature and ability to provide multi-parametric images and its better image quality over other techniques. It provides good soft-tissue contrast and is usable even when a bone or an air space lies between the probe and the target. In addition, MRI can noninvasively monitor tissue temperature changes and provide three-dimensional orientation during surgery. As noted above, MRI has been increasingly used for several different methods of guiding ablation. However, owing to the lack of such studies, we performed a systematic review and pooled analysis to evaluate the safety and efficacy of the different magnetic resonance (MR)-guided ablation methods used in the treatment of liver tumors.
| > Materials and Methods|| |
Using the PubMed, Web of Science, Embase, and Cochrane Library databases, a comprehensive literature search was performed for clinical trials published from January 1997 to October 2019. Specific search terms included the following: (liver tumor OR liver cancer OR liver neoplasm OR HCC), (MRI OR MR imaging OR MR-guided OR MRI) and ablation. Reference lists from retrieved articles were searched for additional studies that may have been missed during the database searches.
Inclusion and exclusion criteria
To be eligible for analysis, studies had to include the following: (1) patients with primary or metastatic liver tumors; (2) MR-guided ablation treatment; and (3) information on the outcomes of patients who underwent these treatments. Outcome data included complication rates, complete ablation (CA) rates, and prognostic information. Case reports, review articles, articles using animal models, articles not about MR-guided ablation, unpublished data, and publications in languages other than English were excluded from the analysis.
Two investigators (Jianfeng Xiang and Ming Liu) reviewed and identified articles for review. The extracted data, including study characteristics, study population, technical details, and outcome measurements, were recorded using a standardized excel file, and a consensus regarding eligibility was reached on all items.
For the rates of complications, CA, progression-free survival (PFS) and overall survival (OS), proportions and 95% confidence intervals (CIs) were calculated using a binomial distribution. A pooled analysis was used to determine the weighted summary statistics for each of the treatments. Results were presented as pooled proportions for the complication, CA, and survival rates, with 95% CIs. All analyses were done with the R language (www.r-project.org).
| > Results|| |
A flow diagram of our literature search is shown in [Figure 1]. A keyword-based search of the PubMed, Web of Science, Embase, and Cochrane Library databases identified a total of 1615 citations, 421 of which were excluded for being duplicates. After title and abstract review, 1045 studies were excluded for various reasons (759 were not about MR-guided ablation, 141 were reviews, 60 were single case reports, and 85 were about animal models). The full text of the remaining 149 articles and an additional seven studies extracted from references was retrieved for more detailed assessment. One hundred and twenty-six of these studies did not have data about the outcomes of treatment or did not involve MR-guided ablation and were subsequently excluded. As a result, 30 studies were included in the final meta-analysis.
|Figure 1: A flow chart showing the selection of studies for the analysis|
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Baseline characteristics of the included studies are summarized in [Table 1]. The 30 studies were published between January 1997 and October 2019 and involved a total of 2,075 patients. Five studies reported a total of 75 patients treated with MR-guided MWA, 15 described 478 treated with MR-guided RFA, eight provided data for 1,468 treated with MR-guided LITT, two reported findings for a total of 47 treated with MR-guided percutaneous cryoablation (PC), and one described seven treated with MR-guided PEI. Of these 30 studies, 17 were conducted in Germany, five in Japan, two in China, two in Switzerland, one in the USA, one in South Korea, one in Austria, and one in England. Details of the studies are shown in [Table 1].
Complete ablation rates
Twenty-two studies reported the CA rate after treatment, including one of PEI, two of PC,, two of LITT,, four of MWA,,,, and 14 of RFA.,,,,,,,,,,,,, The pooled data showed that the CA rates in patients who underwent RFA, MWA, PEI, LITT, and PC were 95.60%, 98.86%, 85.71%, 77.78%, and 47.92%, respectively [Figure 2].
Occurrence of complications
[Table 2] lists the main adverse events that occurred among the different MR-guided ablation treatments. The main complications reported were pain (27.66%, 13/47) and postablation syndrome (27.66%, 13/47) in the PC group; pleural effusion (8.11%, 119/1,468) and subcapsular hematoma (2.25%, 33/1468) in the LITT group; pleural effusion (2.67%, 2/75) in the MWA group; and subcapsular hematoma (4.18%, 20/478) and postablation syndrome (2.93%, 14/478) in the RFA group.
|Table 2: Complications associated with magnetic resonance-guided ablation|
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Progression-free survival rates
Only nine studies evaluated PFS rates, including two analyses about LITT, both of which reported the 3- and 6-month PFS rates,, and one of which included the 12-month PFS rate. There were seven other studies that reported the 12-month PFS rates, including one about PEI, two about MWA,, and four about RFA.,,,
As shown in [Figure 3], when we pooled the two LITT studies, we found that their 3- and 6-month PFS rates and 95% CIs were 98.72% (97.95%–99.49%) and 96.98% (95.96%–98.00%), respectively. The 12-month PFS rate and 95% CI were 85.71% (60.20%–100%) in the PEI study, 63.79% (56.00%–71.60%) in the pooled RFA studies, 69.40% (57.60%–81.20%) in the LITT study, and 47.22% (31.50%–62.90%) in the pooled MWA studies.
|Figure 3: The PFS rates and 95% confidence intervals for the studies. The PFS rates are shown for (a) 3 months, (b) 6 months, and (c) 12 months. PFS = Progression-free survival|
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Overall survival rate
Six studies reported the OS rates.,,,,, Five studies (147 patients) reported the 1-year OS, five (121 patients) the 3 year, and three (44 patients) the 5 year. The results are shown in [Figure 4]. The 1-, 3-, and 5-year OS estimates and their 95% CIs were 88.00% (72.30%–100%), 47.00% (23.50%–70.50%), and 17.00% (0%–34.60%) for LITT; 95.10% (91.20%–99.00%), 76.83% (67.00%–86.60%), and 27.00% (11.00%–51.00%) for RFA; not reported, 66.67% (29.40%–103.90%), and 33.33% (0%–70.60%) for MWA; and 91.49% (83.70%–99.30%), 79.3% (59.70%–98.90%), and not reported for PC.
|Figure 4: The OS rates and 95% confidence intervals for the studies. The OS rates at (a) 1 year, (b) 3 years, and (c) 5 years postprocedure OS = Overall survival|
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| > Discussion|| |
Until recently, most patients with hepatic tumors were unable to undergo liver resection, and those who did had a poor prognosis because of advanced cancer or liver dysfunction. However, the development of novel, minimally invasive ablative treatments, including LITT, RFA, and MWA, has provided the better control of malignant hepatic disease.
Computed tomography (CT) and ultrasound (US), either separately or in combination, have typically been used as navigation tools for these ablation treatments., However, there are some disadvantages to these modalities. For example, CT guidance cannot be used for real-time monitoring and leads to considerable radiation exposure for the surgical team, especially when performed as an in-room procedure. US is also widely used as a real-time, image-guided modality; however, it is associated with image disturbances caused by the generation of micro-bubbles during ablation. Accordingly, real-time MR guidance has been used as a reliable and radiation-free monitoring tool for LITT, RFA, and MWA.,,,,,,, Numerous studies have demonstrated the safety and efficacy of MR-guided ablation treatments.
No systematic and pooled analysis has been published about these approaches, to our knowledge, despite the apparent advantages of MR-guided ablation. To this end, the present study was conducted to summarize the safety, efficacy, and prognosis of these MR-guided ablation treatments. Of the MR-guided ablation treatments, we found that MR-guided RFA studies were the most numerous with 15 related studies, while MR-guided LITT were the second most numerous with eight. However, MR-guided MWA has been garnering more attention recently, with four out of five of the analyzed studies having been published after 2014. In addition, we found that MR-guided RFA and MWA have relatively high CA rates (>90%) and low occurrences of complications (<15%). However, few studies have reported the prognosis of PFS and OS. There are several limitations that need to be addressed. First, this was a systematic review and pooled analysis based on published studies – there is inherent heterogeneity among the different study populations, designs, and outcomes. Second, most MR-guided ablation studies reported a limited number of cases and without randomization or a control group. Third, the systems, sequences, and strengths of MR used in the different studies were different. This may be one reason for the different outcomes. Fourth, follow-up times were typically short, with the final overall prognosis missing from several studies. Although these limitations are significant, they are typical in the context of interventional studies performed with any new methods. In our view, this emphasizes the importance of pooled studies as a source of information regarding these techniques before their more widespread adaptation.
| > Conclusions|| |
We systematically reviewed the outcomes of MR-guided ablation treatments and we suggest them for liver tumors as an alternative treatment, especially MR-guided RFA and MWA, which have high rates of CA and low occurrences of complications. However, studies with larger sample sizes and long-term prognosis are still needed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| > References|| |
European Association for Study of Liver, European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma. Eur J Cancer 2012;48:599-641.
Hwang JE, Kim SH, Jin J, Hong JY, Kim MJ, Jung SH, et al
. Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer. Clin Exp Metastasis 2014;31:25-32.
Adam R, Lucidi V, Bismuth H. Hepatic colorectal metastases: Methods of improving resectability. Surg Clin North Am 2004;84:659-71.
Adams RB, Aloia TA, Loyer E, Pawlik TM, Taouli B, Vauthey JN, et al
. Selection for hepatic resection of colorectal liver metastases: Expert consensus statement. HPB (Oxford) 2013;15:91-103.
Kim JW, Shin SS, Heo SH, Hong JH, Lim HS, Seon HJ, et al
. Ultrasound-guided percutaneous radiofrequency ablation of liver tumors: How we do it safely and completely. Korean J Radiol 2015;16:1226-39.
Gillams A, Goldberg N, Ahmed M, Bale R, Breen D, Callstrom M, et al
. Thermal ablation of colorectal liver metastases: A position paper by an international panel of ablation experts, The Interventional Oncology Sans Frontières meeting 2013. Eur Radiol 2015;25:3438-54.
Lee JW, Choi MH, Lee YJ, Ali B, Yoo HM, Song KY, et al
. Radiofrequency ablation for liver metastases in patients with gastric cancer as an alternative to hepatic resection. BMC Cancer 2017;17:185.
Changyong E, Wang D, Yu Y, Liu H, Ren H, Jiang T. Efficacy comparison of radiofrequency ablation and hepatic resection for hepatocellular carcinoma: A meta-analysis. J Cancer Res Ther 2017;13:625-30.
Wu M, Gao S, Song H, Zhang Z, Wang J, Liu R, et al
. Percutaneous thermal ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma ≤5 cm. J Cancer Res Ther 2019;15:766-72.
Weiss J, Hoffmann R, Rempp H, Keβler DE, Pereira PL, Nikolaou K, et al
. Feasibility, efficacy, and safety of percutaneous MR-guided ablation of small (≤12 mm) hepatic malignancies. J Magn Reson Imaging 2019;49:374-81.
Hoffmann R, Rempp H, Kessler DE, Weiss J, Pereira PL, Nikolaou K, et al
. MR-guided microwave ablation in hepatic tumours: Initial results in clinical routine. Euro Radiol 2017;27:1467-76.
Murakami K, Naka S, Shiomi H, Akabori H, Kurumi Y, Morikawa S, et al
. Initial experiences with MR Image-guided laparoscopic microwave coagulation therapy for hepatic tumors. Surg Today 2015;45:1173-8.
Abe H, Kurumi Y, Naka S, Shiomi H, Umeda T, Naitoh H, et al
. Open-configuration MR-guided microwave thermocoagulation therapy for metastatic liver tumors from breast cancer. Breast Cancer 2005;12:26-31.
Morikawa S, Inubushi T, Kurumi Y, Naka S, Sato K, Tani T, et al
. MR-guided microwave thermocoagulation therapy of liver tumors: Initial clinical experiences using a 0.5 T open MR system. J Magn Reson Imaging 2002;16:576-83.
Yuan C, Yuan Z, Cui X, Gao W, Zhao P, He N, et al
. Efficacy of ultrasound-, computed tomography-, and magnetic resonance imaging-guided radiofrequency ablation for hepatocellular carcinoma. J Cancer Res Ther 2019;15:784-92.
Clasen S, Rempp H, Hoffmann R, Graf H, Pereira PL, Claussen CD. Image-guided radiofrequency ablation of hepatocellular carcinoma (HCC): Is MR guidance more effective than CT guidance? Eur J Radiol 2014;83:111-6.
Hoffmann R, Rempp H, Syha R, Ketelsen D, Pereira PL, Claussen CD, et al
. Transarterial chemoembolization using drug eluting beads and subsequent percutaneous MR-guided radiofrequency ablation in the therapy of intermediate sized hepatocellular carcinoma. Eur J Radiol 2014;83:1793-8.
Rempp H, Hoffmann R, Roland J, Buck A, Kickhefel A, Claussen CD, et al
. Threshold-based prediction of the coagulation zone in sequential temperature mapping in MR-guided radiofrequency ablation of liver tumours. Eur Radiol 2012;22:1091-100.
Rempp H, Waibel L, Hoffmann R, Claussen CD, Pereira PL, Clasen S. MR-guided radiofrequency ablation using a wide-bore 1.5-T MR system: Clinical results of 213 treated liver lesions. Eur Radiol 2012;22:1972-82.
Clasen S, Rempp H, Boss A, Schmidt D, Fritz J, Schraml C, et al
. MR-guided radiofrequency ablation of hepatocellular carcinoma: Long-term effectiveness. J Vascular Interve Radiol 2011;22:762-70.
Terraz S, Cernicanu A, Lepetit-Coiffé M, Viallon M, Salomir R, Mentha G, et al
. Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: Progress in targeting and preliminary observations with temperature monitoring. Eur Radiol 2010;20:886-97.
Maeda T, Hong J, Konishi K, Nakatsuji T, Yasunaga T, Yamashita Y, et al
. Tumor ablation therapy of liver cancers with an open magnetic resonance imaging-based navigation system. Surg Endoscopy 2009;23:1048-53.
Clasen S, Boss A, Schmidt D, Schraml C, Fritz J, Schick F, et al
. MR-guided radiofrequency ablation in a 0.2-T open MR system: Technical success and technique effectiveness in 100 liver tumors. J Magn Reson Imaging 2007;26:1043-52.
Gaffke G, Gebauer B, Knollmann FD, Helmberger T, Ricke J, Oettle H, et al
. Use of semiflexible applicators for radiofrequency ablation of liver tumors. Cardiovasc Interv Radiol 2006;29:270-5.
Mahnken AH, Buecker A, Spuentrup E, Krombach GA, Henzler D, Günther RW, et al
. MR-guided radiofrequency ablation of hepatic malignancies at 1.5 T: Initial results. J Magn Reson Imaging 2004;19:342-8.
Kettenbach J, Kostler W, Rucklinger E, Gustorff B, Hupfl M, Wolf F, et al
. Percutaneous saline-enhanced radiofrequency ablation of unresectable hepatic tumors: Initial experience in 26 patients. AJR Am J Roentgenol 2003;180:1537-45.
Kelekis AD, Terraz S, Roggan A, Terrier F, Majno P, Mentha G, et al
. Percutaneous treatment of liver tumors with an adapted probe for cooled-tip, impedance-controlled radio-frequency ablation under open-magnet MR guidance: Initial results. Eur Radiol 2003;13:1100-5.
Lewin JS, Connell CF, Duerk JL, Chung YC, Clampitt ME, Spisak J, et al
. Interactive MRI-guided radiofrequency interstitial thermal ablation of abdominal tumors: Clinical trial for evaluation of safety and feasibility. J Magn Reson Imaging 1998;8:40-7.
Eichler K, Zangos S, Gruber-Rouh T, Vogl TJ, Mack MG. MR-guided laser-induced thermotherapy (LITT) in patients with liver metastases of uveal melanoma. J Eur Acad Dermatol Venereol 2014;28:1756-60.
Kickhefel A, Rosenberg C, Roland J, Viallon M, Gross P, Schick F, et al
. A pilot study for clinical feasibility of the near-harmonic 2D referenceless PRFS thermometry in liver under free breathing using MR-guided LITT ablation data. Int J Hyperthermia 2012;28:250-66.
Vogl TJ, Naguib NN, Eichler K, Lehnert T, Ackermann H, Mack MG. Volumetric evaluation of liver metastases after thermal ablation: Long-term results following MR-guided laser-induced thermotherapy. Radiology 2008;249:865-71.
Zangos S, Eichler K, Balzer JO, Straub R, Hammerstingl R, Herzog C, et al
. Large-sized hepatocellular carcinoma (HCC): A neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT). Eur Radiol 2007;17:553-63.
Pech M, Wieners G, Freund T, Dudeck O, Fischbach F, Ricke J, et al
. MR-guided interstitial laser thermotherapy of colorectal liver metastases: Efficiency, safety and patient survival. Eur J Med Res 2007;12:161-8.
Vogl TJ, Straub R, Zangos S, Mack MG, Eichler K. MR-guided laser-induced thermotherapy (LITT) of liver tumours: Experimental and clinical data. Int J Hyperthermia 2004;20:713-24.
Puls R, Kroncke TJ, Kluner C, Gaffke G, Stroszczynski C, Albrecht T, et al
. Double contrast MRI of thermally ablated liver metastases. RoFo Fortschritte Gebiete Rontgenstrahlen Nuklearmedizin 2003;175:1467-70.
Dick EA, Joarder R, de Jode M, Taylor-Robinson SD, Thomas HC, Foster GR, et al
. MR-guided laser thermal ablation of primary and secondary liver tumours. Clin Radiol 2003;58:112-20.
Wu B, Xiao YY, Zhang X, Zhang AL, Li HJ, Gao DF. Magnetic resonance imaging-guided percutaneous cryoablation of hepatocellular carcinoma in special regions. Hepatobiliary Pancreatic Dis Int 2010;9:384-92.
Shimizu T, Sakuhara Y, Abo D, Hasegawa Y, Kodama Y, Endo H, et al
. Outcome of MR-guided percutaneous cryoablation for hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 2009;16:816-23.
Kim YJ, Raman SS, Yu NC, Lu DS. MR-guided percutaneous ethanol injection for hepatocellular carcinoma in a 0.2T open MR system. J Magn Reson Imaging 2005;22:566-71.
Ma S, Ding M, Li J, Wang T, Qi X, Shi Y, et al
. Ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma: Clinical outcomes and prognostic factors. J Cancer Res Clin Oncol 2017;143:131-42.
van Tilborg AA, Scheffer HJ, van der Meijs BB, van Werkum MH, Melenhorst MC, van den Tol PM, et al
. Transcatheter CT hepatic arteriography-guided percutaneous ablation to treat ablation site recurrences of colorectal liver metastases: The incomplete ring sign. J Vasc Interv Radiol 2015;26:583-70.
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2]